Results 131 to 140 of about 6,042,835 (382)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

THE DATABASE OF THE AUTHORITATIVE FILE „SUBJECT HEADINGS” IS AN IMPORTANT COMPONENT OF INTEGRATION OF THE EDUCATIONAL LIBRARIES

open access: yesІнформаційні технології і засоби навчання, 2014
The article is focused on the problem of creating a database of the authoritative file of thematic subject headings concerning education, pedagogy and psychology in the electronic catalogue at V.
Nataliia Ye. Zorina
doaj  

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

open access: yesFEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama   +7 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

MeSH Medical Subject Headings

open access: yes, 2023
MesH es Sistema de Organización de Conocimiento digital  que tiene papel protagónico en la organización y recuperación de información científica y de mayor impacto en las biociencias. En el vasto, diverso y complejo mundo de la literatura científica, el Medical Subject Headings (MeSH) de PubMed actúa como un guía, permitiendo a los investigadores ...
openaire   +1 more source

Dynamic literature mapping : typography in screen-based media [PDF]

open access: yes, 2003
This paper chronicles the development of a visual map representing a literature search on key theorists and thinkers in two principal topics: Typography and New Media.
Yee, Joyce
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

Using a Research Log and Reflective Writing to Improve EBP and Information Literacy Skills of BSN Students [PDF]

open access: yes, 2013
Background Baccalaureate nursing educators must prepare nurses to implement evidence-based practice (EBP). BSN nurses must be able to effectively identify, analyze, and synthesize evidence (AACN, 2008).
Whalen, Kimberly J., Zentz, Suzanne E.
core   +1 more source

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