Results 181 to 190 of about 49,524 (290)

N‐of‐1 trials in clinical research: Methodological foundations, statistical approaches and implementation challenges

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
N‐of‐1 trials offer a unique and rigorous methodology for evaluating individualized treatment responses, particularly within the context of personalized medicine. This article provides a comprehensive explanation of the conceptual and methodological underpinnings of N‐of‐1 trials, with particular emphasis on statistical techniques and considerations ...
Marcos Clint Leal De Carvalho   +5 more
wiley   +1 more source

Trust first, concerns second: An international vignette study of older adults' preferences towards deprescribing statins

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract This study investigated the attitudes and beliefs of older adults towards deprescribing statins in Australia, the United Kingdom and the United States, using an online, vignette‐based study. Presented with a hypothetical scenario in which a general practitioner advised stopping simvastatin, participants rated their level of agreement and ...
Sarah E. Vordenberg   +5 more
wiley   +1 more source

Risk of cardiac, neuropsychiatric and musculoskeletal adverse events with levothyroxine: Systematic review

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Levothyroxine (LT4) is the standard treatment for hypothyroidism and the most widely prescribed medication worldwide. Although generally safe, regulatory reports list potential cardiac, neuropsychiatric and musculoskeletal adverse events (AEs). Clarifying their clinical relevance is essential.
Bala Swetha Baskaran   +2 more
wiley   +1 more source

The SPECTACLE Study: A Multicenter, Prospective, Single-Arm Trial Evaluating Quantitative Blood Flow Assessment Using SPY-QP Software in Minimally Invasive Rectal Cancer Surgery. [PDF]

open access: yesAsian J Endosc Surg
Hamabe A   +15 more
europepmc   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

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