Results 91 to 100 of about 49,090 (277)

Development of a sublingual allergy vaccine for grass pollinosis

, 2010
Franco Frati1,2, Silvia Scurati1, Paola Puccinelli1, Marie David3, Cecile Hilaire4, Maurizio Capecce4, Francesco Marcucci2, Cristoforo Incorvaia51Medical and Scientific Department, Stallergenes, Milan, Italy; 2University Department of Medical and ...
Silvia Scurati, Franco Frati, et al, Paola Puccinelli   +3 more
core  

Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection

Frontiers in Immunology, 2019
Respiratory syncytial virus (RSV) is the leading cause of serious respiratory tract disease but there is no licensed RSV vaccine. Immunopathological mechanisms have long been suspected as operating in the development of severe RSV disease and have ...
In Su Cheon, Joo Young Kim, Youngjoo Choi, Byoung-Shik Shim, Jung-ah Choi, Dae-Im Jung, Jae-Ouk Kim, Thomas J. Braciale, Hyewon Youn, Hyewon Youn, Man Ki Song, Jun Chang   +11 more
doaj   +1 more source

Efficacy and Safety of Cannabis Derivates and Their Synthetic Analogs. Overview of Systematic Reviews

Phytotherapy Research, EarlyView.
ABSTRACT The use of medicinal products derived from cannabis and its synthetic analogues has grown in recent years for various health conditions, which led to an increase in systematic reviews (SR) on the topic. The objective of this overview was to identify, synthesize, and critically appraise the evidence from SR on the benefits and harms of cannabis
Rafael Leite Pacheco, Daniela Fortunato Rêgo, Carolina de Oliveira Cruz Latorraca, Marco Aurelio de Carvalho Nascimento, André Bastos Daher, Rachel Riera   +5 more
wiley   +1 more source

Sublingual Drug Delivery

, 2008
The sublingual route is one of the early modes of administration for systemic drug delivery. This route avoids first-pass metabolism and affords quick drug entry into the systemic circulation.
Li, Xiaoling, Goswami, Tarun, Jasti, Bhaskara   +2 more
core   +1 more source

Network mapping of MRI‐defined anatomical invasion phenotypes for prognostic stratification in oral tongue squamous cell carcinoma

VIEW, EarlyView.
Abstract The AJCC/UICC clinical T staging for oral tongue squamous cell carcinoma (OTSCC) primarily relies on radiological depth of invasion (rDOI) and may not capture complex oral structure invasion (OSI). Therefore, we developed a magnetic resonance imaging (MRI)‐based risk stratification system integrating rDOI and OSI and explored the association ...
Jie Pan, Sisi Huang, Fei Xie, Hui Xie, Zhiying Liang, Guangying Ruan, Shuqi Li, Chao Luo, Fengze Wu, Haojiang Li, Lizhi Liu, Wenjie Huang   +11 more
wiley   +1 more source

Critical constraints to ecological buffering in a rapidly changing Arctic: A long‐term seabird study

Journal of Animal Ecology, EarlyView.
Drawing on two decades of research in East Greenland, this study shows that little auks, key seabird indicators of Arctic ecosystem health, can adapt to rapid environmental change through behavioural flexibility. However, increasing storms and mercury pollution are pushing resilience to its limits, providing an early warning of broader Arctic ...
David Grémillet, Françoise Amélineau, Ann M. A. Harding, Jérôme Fort   +3 more
wiley   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

Diverse Mechanisms of Allergen Specific Immunotherapy

RUDN Journal of Medicine, 2019
Allergen immunotherapy (AIT) is widely used to establish a tolerant immune response and it is currently the only disease modifying treatment. There are different routes to administer the allergen, including subcutaneous, sublingual, intralymphatic ...
Lacin Cevhertas, Mübeccel Akdis
doaj   +1 more source

Preventive Application of House Dust Mite‐Sublingual Immunotherapy Induces Blocking Antibodies in Sensitized Preschool Children

Allergy, EarlyView.
HDM‐pSLIT induced IgG, IgG1, and IgG4 specific to major HDM allergens in sensitized non‐allergic preschool children without increasing HDM‐sIgE. It blunted the development of new sensitizations and reduced HDM reactivity in skin and basophils. HDM‐pSLIT treated children displayed a blocking effect on HDM‐induced basophil activation.
Varsha Dwivedi, Klara Schmidthaler, Hilal Demir, Justyna Sieber, René Gaupmann, Livia Mia Gona‐Höpler, Christina Bannert, Saskia Gruber, Eleonora Dehlink, Thomas Eiwegger, Alexandra Graf, Barbara Bohle, Zsolt Szépfalusi   +12 more
wiley   +1 more source

Extracts from The Cochrane Library: Sublingual immunotherapy for allergic rhinitis.

, 2011
The "Cochrane Corner" is a quarterly section in the Journal that highlights systematic reviews relevant to otolaryngology-head and neck surgery, with invited commentary to aid clinical decision making. This installment features an updated Cochrane Review
John H. Krouse, Martin J. Burton, Richard M. Rosenfeld   +2 more
core   +1 more source