Premedication of Pediatric Cardiac Population with Midazolam: Comparison of Oral and Sublingual Administration Regarding Plasma Midazolam Concentration, Clinical Effectiveness, Hemodynamic and Behavioral Outcomes [PDF]
ChildrenBackground: Midazolam is widely used as a pediatric premedication, but evidence from direct comparisons of oral and sublingual administration in children with congenital heart disease remains limited, particularly that from pharmacokinetic and ...
Theofili Kousi +9 more
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Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men [PDF]
Scientific ReportsSublingual administration of nicotinamide mononucleotide (NMN) is hypothesized to enhance systemic bioavailability by bypassing hepatic first-pass metabolism, a significant limitation of oral intake.
Jun Wakabayashi +2 more
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Tinnitus after administration of sublingual immunotherapy [PDF]
SAGE Open Medical Case Reports, 2017 Background/objectives: Sublingual immunotherapy was first described in 1986. Since then, its use has been increased as an alternative to subcutaneously administered immunotherapy in the treatment of allergic rhinitis.
Jacob Juel
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Assessment of Bioavailability and Related Bioactivity of Hydroxycinnamic Acids [PDF]
Current Issues in Molecular BiologyThe aim of the present study was to evaluate the bioavailability and associated bioactivity of p-coumaric (p-COA), caffeic (CA), and ferulic (FA) hydroxycinnamic acids (HCAs) isolated from an aqueous extract of plant material.
Elica Valkova +4 more
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Advances in Nanoparticulate Drug Delivery Approaches for Sublingual and Buccal Administration
Frontiers in Pharmacology, 2019 The sublingual and buccal routes of administration have significant advantages for both local and systemic drug delivery. They have shown to be an effective alternative to the traditional oral route, especially when fast onset of action is required ...
Susan Hua, Susan Hua
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Sublingual vs. vaginal misoprostol for cervical preparation before surgical abortion in the first trimester [PDF]
New Indian Journal of OBGYN, 2023 Background: Suction evacuation is the most common surgical method of first-trimester pregnancy termination and cervical dilatation is the most critical step.
Neeru Malik +5 more
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Development of Sedative Dexmedetomidine Sublingual In Situ Gels: In Vitro and In Vivo Evaluations
Pharmaceutics, 2022 Intravenous dexmedetomidine (DEX) is currently approved by the FDA for the sedation of intubated patients in intensive care units to reduce anxiety and to augment postoperative analgesia.
Ayat A. Allam +10 more
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Sublingual Administration of Drugs [PDF]
Anesthesiology, 1944 In discussions of therapeutic technics there is frequently recurring opinion to the effect that any of the potent nonirritant drugs may be effectively administered by simple application to the oral mucosa. 1 Very few drugs, however, are routinely used in this way in regular practice.
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Comparative study of sublingual versus vaginal misoprostol following mifepristone in early first trimester medical termination of pregnancy - a prospective study [PDF]
New Indian Journal of OBGYN, 2019 Aim: To compare the efficacy and side effects of sublingual versus vaginal administration of misoprostol after a single oral dose of 200 mg of mifepristone in termination of early first trimester pregnancy. Methods: This is a randomised prospective study
B. L Pathak, Shikha Hajong Roy
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Frontiers in Medicine, 2022 BackgroundThe effects of anesthesia administration on sublingual microcirculation are unknown. It is unclear how sublingual microcirculation responds to ephedrine or phenylephrine administration.
Yanbing Zhang +4 more
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