Results 191 to 200 of about 1,886 (262)

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

open access: yesThe FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi   +12 more
wiley   +1 more source

Improving solar PV performance under bird-dropping conditions with a dual-cooling approach. [PDF]

open access: yesSci Rep
Ali KAM   +4 more
europepmc   +1 more source

Resolving three GABA induced electrogenic events and GABA‐coupling stoichiometry for Na+ and Cl− in hGAT‐1

open access: yesThe FEBS Journal, EarlyView.
Using solid‐supported membrane electrophysiology, we resolved three electrogenic events during GABA transport by the human GAT‐1 transporter. A rapid occlusion step (E1) is followed by a GABA‐induced Na+ leak current (E2), which becomes prominent under steep Na+ gradients, and a slower current associated with Na+‐coupled GABA transport (E3 ...
Rocco Zerlotti   +8 more
wiley   +1 more source

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