The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati +4 more
wiley +1 more source
Numerical computation and experimental assessment of a pressure-retaining gas-tight sediment sampler. [PDF]
He S, Xie Y, Bai H, Peng Y, Jin Y.
europepmc +1 more source
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source
Improving solar PV performance under bird-dropping conditions with a dual-cooling approach. [PDF]
Ali KAM +4 more
europepmc +1 more source
Using solid‐supported membrane electrophysiology, we resolved three electrogenic events during GABA transport by the human GAT‐1 transporter. A rapid occlusion step (E1) is followed by a GABA‐induced Na+ leak current (E2), which becomes prominent under steep Na+ gradients, and a slower current associated with Na+‐coupled GABA transport (E3 ...
Rocco Zerlotti +8 more
wiley +1 more source
Symmetrical pH Electrochemical Cell Coupled to Constant Potential Coulometry for Improved Sensitivity and Precision: Part 1. Fundamental Considerations. [PDF]
Nussbaum R +3 more
europepmc +1 more source
A lightweight metaheuristic-driven adaptive PID approach for nonlinear conical tank regulation. [PDF]
Rajaram K, Kathirvel M, Subburathinam K.
europepmc +1 more source
Study on the Tribological Properties of Multilayer Concentric Hexagonal Laser Texturing on Rubber Surfaces of Screw Pumps. [PDF]
Liu X +8 more
europepmc +1 more source
An experimental evaluation of vibration patterns arising from vortex flow in mixed flow pumps a case study in Upper Egypt. [PDF]
El-Gazzar DMS +2 more
europepmc +1 more source
A method for evaluating safety reliability of descend/ascend drop-weight system and mission abort decision for deep-ocean scientific human submersibles. [PDF]
Palaniappan M +4 more
europepmc +1 more source

