Results 21 to 30 of about 429 (140)

Deep learning identify retinal nerve fibre and choroid layers as markers of age‐related macular degeneration in the classification of macular spectral‐domain optical coherence tomography volumes

Acta Ophthalmologica, Volume 100, Issue 8, Page 937-945, December 2022., 2022
Abstract Purpose Deep learning models excel in classifying medical image data but give little insight into the areas identified as pathology. Visualization of a deep learning model’s point of interest (POI) may reveal unexpected areas associated with diseases such as age‐related macular degeneration (AMD).
Arnt‐Ole Tvenning, Stian Rikstad Hanssen, Dordi Austeng, Tora Sund Morken   +3 more
wiley   +1 more source

Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives

Graefe's Archive for Clinical and Experimental Ophthalmology, 2023
Abstract Purpose Subretinal drusenoid deposits (SDDs) are distinct extracellular alteration anterior to the retinal pigment epithelium (RPE). Given their commonly uniform phenotype, a hereditary predisposition seems likely. Hence, we aim to investigate prevalence and determinants in patients’ first-degree relatives.
Mauschitz, Matthias M., Hochbein, Benedikt J., Klinkhammer, Hannah, Saßmannshausen, Marlene, Terheyden, Jan H., Krawitz, Peter, Finger, Robert P.   +6 more
openaire   +3 more sources

ACQUIRED VITELLIFORM DETACHMENT IN PATIENTS WITH SUBRETINAL DRUSENOID DEPOSITS (RETICULAR PSEUDODRUSEN) [PDF]

Retina, 2011
To report a recently observed association of macular vitelliform detachment and subretinal drusenoid deposits (reticular pseudodrusen).Clinical and multimodal imaging data of patients with acquired vitelliform lesions in association with subretinal drusenoid deposits were reviewed.
Zweifel, S A, Spaide, R F, Yannuzzi, L A
openaire   +3 more sources

Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases

BMJ Open Ophthalmology, 2022
Background/aims Demonstrate that subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are linked to coexistent high-risk vascular diseases (HRVDs). Methods Cross-sectional study. Two hundred AMD subjects (aged 51–100 years;
Gerardo Ledesma-Gil, Oscar Otero-Marquez, Sharmina Alauddin, Yuehong Tong, Katy Tai, Harriet Lloyd, Micaela Koci, Maria Scolaro, Cinthi Pillai, Catherine Ye, Arun Govindaiah, Alauddin Bhuiyan, Mandip S Dhamoon, Avnish Deobhakta, Gareth Lema, Jagat Narula, Richard B Rosen, Lawrence A Yannuzzi, K Bailey Freund, Roland Theodore Smith   +19 more
openaire   +2 more sources

Retracted: Subretinal Drusenoid Deposits and Lower Serum High‐Density Lipoprotein Cholesterol Levels Possess Latent Relation to Cardiovascular Disease and Can Be a Feasible Predictor

, 2023
Computational and Mathematical Methods in Medicine, Volume 2023, Issue 1, 2023.
Computational and Mathematical Methods in Medicine
wiley   +1 more source

SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION [PDF]

Retina, 2013
To characterize the morphology, prevalence, and topography of subretinal drusenoid deposits, a candidate histological correlate of reticular pseudodrusen, with reference to basal linear deposit (BlinD), a specific lesion of age-related macular degeneration, and to propose a biogenesis model for both lesion.Donor eyes with median death-to-preservation ...
Christine A, Curcio, Jeffrey D, Messinger, Kenneth R, Sloan, Gerald, McGwin, Nancy E, Medeiros, Richard F, Spaide   +5 more
openaire   +2 more sources

Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

Biomedical Optics Express, 2014
Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded ...
Alexander, Meadway, Xiaolin, Wang, Christine A, Curcio, Yuhua, Zhang   +3 more
openaire   +2 more sources

Photoreceptor Perturbation Around Subretinal Drusenoid Deposits as Revealed by Adaptive Optics Scanning Laser Ophthalmoscopy [PDF]

American Journal of Ophthalmology, 2014
To describe the microscopic structure of photoreceptors impacted by subretinal drusenoid deposits, also called pseudodrusen, an extracellular lesion associated with age-related macular degeneration (AMD), using adaptive optics scanning laser ophthalmoscopy (AOSLO).Observational case series.We recruited 53 patients with AMD and 10 age-similar subjects ...
Yuhua, Zhang, Xiaolin, Wang, Ernesto Blanco, Rivero, Mark E, Clark, Clark Douglas, Witherspoon, Richard F, Spaide, Christopher A, Girkin, Cynthia, Owsley, Christine A, Curcio   +8 more
openaire   +2 more sources

Association of subretinal drusenoid deposits and cardiovascular disease

Scientific Reports
The presence of subretinal drusenoid deposits (SDDs) in patients with age-related macular degeneration (AMD) appears to be correlated with cardiovascular disease (CVD) and may serve as a useful tool for predicting certain forms of CVD. Here, we tested this hypothesis by examining whether patients with AMD with SDDs are more likely to have a ...
Natan Lishinsky-Fischer, Kinneret Misgav, Itay Chowers, Liran Tiosano, Yahel Shwartz, Jaime Levy   +5 more
openaire   +3 more sources

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source