Results 21 to 30 of about 740 (185)

SUBRETINAL DRUSENOID DEPOSIT IN AGE-RELATED MACULAR DEGENERATION: Histologic Insights Into Initiation, Progression to Atrophy, and Imaging. [PDF]

Retina, 2020
Purpose: To clarify the role of subretinal drusenoid deposits (SDD; pseudodrusen) in the progression of age-related macular degeneration through high-resolution histology. Methods: In 33 eyes of 32 donors (early age-related macular degeneration, n = 15; geographic atrophy, n = 9 ...
Chen L, Messinger JD, Zhang Y, Spaide RF, Freund KB, Curcio CA.   +5 more
europepmc   +4 more sources

Prevalence and determinants of subretinal drusenoid deposits in patients’ first-degree relatives [PDF]

Graefe's Archive for Clinical and Experimental Ophthalmology, 2023
Abstract Purpose Subretinal drusenoid deposits (SDDs) are distinct extracellular alteration anterior to the retinal pigment epithelium (RPE). Given their commonly uniform phenotype, a hereditary predisposition seems likely. Hence, we aim to investigate prevalence and determinants in patients’ first-degree relatives.
Matthias M. Mauschitz, Benedikt J Hochbein, Hannah Klinkhammer, Marlene Saßmannshausen, Jan Henrik Terheyden, Peter Krawitz, Robert P. Finger   +6 more
openalex   +4 more sources

SUBRETINAL DRUSENOID DEPOSITS IN NON-NEOVASCULAR AGE-RELATED MACULAR DEGENERATION [PDF]

Retina, 2012
To characterize the morphology, prevalence, and topography of subretinal drusenoid deposits, a candidate histological correlate of reticular pseudodrusen, with reference to basal linear deposit (BlinD), a specific lesion of age-related macular degeneration, and to propose a biogenesis model for both lesion.Donor eyes with median death-to-preservation ...
Christine A. Curcio, Jeffrey D. Messinger, Kenneth R. Sloan, Gerald McGwin, Nancy E. Medeiros, Richard F. Spaide   +5 more
openalex   +4 more sources

Correlation between ellipsoid zone thickness and the presence of subretinal drusenoid deposits in age-related macular degeneration. [PDF]

BMJ Open Ophthalmol
Bellis RM, Fei Y, Le B, Ledesma-Gil G, Otero-Marquez O, Tong Y, Tai K, Rosen RB, Lema GMC, Smith RT.   +9 more
europepmc   +3 more sources

Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

Biomedical Optics Express, 2014
Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded ...
Alexander Meadway, Xiaolin Wang, Christine A. Curcio, Yuhua Zhang   +3 more
openalex   +3 more sources

Visual function in aging and age-related macular degeneration including subretinal drusenoid deposits [PDF]

, 2021
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the developed world among people over 50 years of age. Although AMD is clinically characterised by the presence of drusen, subretinal drusenoid deposits (SDD) have also ...
Grewal, Manjot Kaur
core   +2 more sources

Biologically Guided Optimization of Test Target Location for Rod-mediated Dark Adaptation in Age-related Macular Degeneration

Ophthalmology Science, 2023
Purpose: We evaluate the impact of test target location in assessing rod-mediated dark adaptation (RMDA) along the transition from normal aging to intermediate age-related macular degeneration (AMD).
Cynthia Owsley, PhD, MSPH, Thomas A. Swain, MPH, Gerald McGwin, Jr., PhD, MS, Mark E. Clark, MEng, Deepayan Kar, MS, Christine A. Curcio, PhD   +5 more
doaj   +1 more source

Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects. [PDF]

Int J Retina Vitreous
Tan JM, Fei Y, Wang L, Otero-Marquez O, Bhuiyan TR, Arevalo JF, Lema GMC, Smith RT.   +7 more
europepmc   +3 more sources

Internal Carotid Artery Stenosis and Ipsilateral Subretinal Drusenoid Deposits [PDF]

Investigative Opthalmology & Visual Science
Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are strongly associated with vasculopathies such as myocardial infarction and ischemic stroke. This study evaluates ischemic stroke subjects for SDDs to determine whether ocular hypoperfusion from internal carotid artery (ICA) stenosis is associated with ipsilateral SDDs.A ...
Emanuel Mordechaev, Jason J. Jo, Samuel Mordechaev, Arun Govindaiah, Yang Fei, Katy Tai, Yuehong Tong, Alauddin Bhuiyan, Jesse Weinberger, Avnish Deobhakta, Mandip S. Dhamoon, Richard B. Rosen, Gareth Lema, R. Theodore Smith   +13 more
openalex   +3 more sources

Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits [PDF]

Journal of Clinical Medicine, 2020
Purpose: To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), intermediate AMD (iAMD) with no SDD (
Manjot Grewal, Shruti Chandra, Sarega Gurudas, Alan C. Bird, Glen Jeffery, Sobha Sivaprasad   +5 more
openalex   +5 more sources