Results 31 to 40 of about 429 (140)

Retinal Pigment Epithelium Degeneration Associated With Subretinal Drusenoid Deposits in Age-Related Macular Degeneration [PDF]

American Journal of Ophthalmology, 2017
To test whether increased light transmission (hypertransmission) through subretinal drusenoid deposits (SDD) into the choroid in age-related macular degeneration (AMD) represented retinal pigment epithelium (RPE) degeneration.Cross-sectional study.Nineteen eyes of 12 patients with early- to intermediate-stage AMD and 18 eyes of 12 normal subjects were ...
Xiaoyu Xu, Xing Liu, Xiaolin Wang, Mark E. Clark, Gerald McGwin, Cynthia Owsley, Christine A. Curcio, Yuhua Zhang   +7 more
openaire   +2 more sources

Spatial Dissociation of Subretinal Drusenoid Deposits and Impaired Scotopic and Mesopic Sensitivity in AMD

Investigative Opthalmology & Visual Science, 2022
Subretinal drusenoid deposits (SDD) first appear in the rod-rich perifovea and can extend to the cone-rich fovea. To refine the spatial relationship of visual dysfunction with SDD burden, we determined the topography of mesopic and scotopic light sensitivity in participants with non-neovascular AMD with and without SDD.Thirty-three subjects were ...
Zhang, Yuhua, Sadda, SriniVas R., Sarraf, David, Swain, Thomas A., Clark, Mark E., Sloan, Kenneth R., Warriner, William E., Owsley, Cynthia, Curcio, Christine A.   +8 more
openaire   +2 more sources

Visual Function Assessment in Geographic Atrophy: A Review

Clinical &Experimental Ophthalmology, Volume 54, Issue 2, Page 260-274, March 2026.
ABSTRACT Geographic atrophy (GA) causes significant vision impairment and reduction in vision‐related quality of life. Fundus autofluorescence (FAF) is the gold standard of structural assessment of GA but is a surrogate marker for vision loss, which can be assessed by tests of visual function and functional vision.
Ye Li, Lauren N. Ayton, Adrian T. Fung
wiley   +1 more source

Deep Learning‐Based Detection of Reticular Pseudodrusen in Age‐Related Macular Degeneration

Clinical &Experimental Ophthalmology, Volume 54, Issue 1, Page 78-85, January/February 2026.
ABSTRACT Background Reticular pseudodrusen (RPD) signify a critical phenotype driving vision loss in age‐related macular degeneration (AMD). This study sought to develop and externally test a deep learning (DL) model to detect RPD on optical coherence tomography (OCT) scans with expert‐level performance.
Himeesh Kumar, Yelena Bagdasarova, Scott Song, Doron G. Hickey, Amy C. Cohn, Mali Okada, Robert P. Finger, Jan H. Terheyden, Ruth E. Hogg, Pierre‐Henry Gabrielle, Louis Arnould, Maxime Jannaud, Xavier Hadoux, Peter van Wijngaarden, Carla J. Abbott, Lauren A. B. Hodgson, Roy Schwartz, Adnan Tufail, Emily Y. Chew, Cecilia S. Lee, Erica L. Fletcher, Melanie Bahlo, Brendan R. E. Ansell, Alice Pébay, Robyn H. Guymer, Aaron Y. Lee, Zhichao Wu   +26 more
wiley   +1 more source

Ten‐Year Incidence, Risk Factors and Progression Rate of Macular Atrophy in Neovascular Age‐Related Macular Degeneration

Clinical &Experimental Ophthalmology, Volume 54, Issue 1, Page 55-66, January/February 2026.
ABSTRACT Background To evaluate the 10‐year cumulative incidence, progression rates, and risk factors for macular atrophy (MA) in neovascular age‐related macular degeneration (nAMD) patients receiving long‐term anti‐vascular endothelial growth factor (VEGF) therapy.
Francesco Romano, Marco Casaluci, Antonio Valastro, Matteo Airaldi, Paolo Milella, Francesco Pozzo Giuffrida, Elisa Cozzi, Andrea Aretti, Kelvin YC Teo, Chui Ming Gemmy Cheung, Marco Nassisi, Francesco Viola, Giovanni Staurenghi, Alessandro Invernizzi   +13 more
wiley   +1 more source

Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits [PDF]

Journal of Clinical Medicine, 2020
Purpose: To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), intermediate AMD (iAMD) with no SDD (
Manjot K. Grewal, Shruti Chandra, Sarega Gurudas, Alan Bird, Glen Jeffery, Sobha Sivaprasad   +5 more
openaire   +3 more sources

Fundus autofluorescence lifetimes in age‐related macular degeneration versus healthy controls in a pseudophakic population

Acta Ophthalmologica, Volume 103, Issue 6, Page e394-e400, September 2025.
Abstract Purpose To check whether prolonged fundus autofluorescence (FAF) lifetimes in age‐related macular degeneration (AMD) could be an artefact resulting from lens fluorescence. Methods Fluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in pseudophakic intermediate AMD as well as healthy controls. The median values of FAF lifetimes in
Jana Oertel, Dominik Fischer, Melih Tarhan, Daniel Meller, Martin Hammer   +4 more
wiley   +1 more source

‘EarlyAMDRate’: A grading instrument for OCT‐based assessment of early lesions caused by age‐related macular degeneration

Acta Ophthalmologica, Volume 103, Issue 5, Page e318-e331, August 2025.
Abstract Background and Objectives Long before any signs of age‐related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina.
Marcus Wagner, Thomas Peschel, Carla J. Leutloff, Franziska G. Rauscher   +3 more
wiley   +1 more source

Internal Carotid Artery Stenosis and Ipsilateral Subretinal Drusenoid Deposits

Investigative Opthalmology & Visual Science
Subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are strongly associated with vasculopathies such as myocardial infarction and ischemic stroke. This study evaluates ischemic stroke subjects for SDDs to determine whether ocular hypoperfusion from internal carotid artery (ICA) stenosis is associated with ipsilateral SDDs.A ...
Mordechaev, Emanuel, Jo, Jason J., Mordechaev, Samuel, Govindaiah, Arun, Fei, Yang, Tai, Katy, Tong, Yuehong, Bhuiyan, Alauddin, Weinberger, Jesse, Deobhakta, Avnish, Dhamoon, Mandip, Rosen, Richard B., Lema, Gareth M. C., Smith, R. Theodore   +13 more
openaire   +2 more sources

The Ercc1−/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration

Aging Cell, Volume 24, Issue 3, March 2025.
Spontaneous endogenous DNA damage drives key hallmarks of age‐related retinal degeneration, including visual impairment, photoreceptor cell loss, dysmorphic RPE, mitochondrial dysfunction, and cellular senescence. Therefore, Ercc1−/Δ mice represent a valuable model for further mechanistic studies on age‐related retinal degeneration and for rapid ...
Akilavalli Narasimhan, Seok Hong Min, Laura L. Johnson, Heidi Roehrich, William Cho, Tracy K. Her, Caeden Windschitl, Ryan D. O'Kelly, Luise Angelini, Matthew J. Yousefzadeh, Linda K. McLoon, William W. Hauswirth, Paul D. Robbins, Dorota Skowronska‐Krawczyk, Laura J. Niedernhofer   +14 more
wiley   +1 more source