Results 41 to 50 of about 429 (140)

Hyperautofluorescent material inside areas of macular atrophy may reveal non‐lipofuscin fluorophores in late stage AMD

Acta Ophthalmologica, Volume 103, Issue 1, Page e66-e75, February 2025.
Abstract Purpose To characterize fundus autofluorescence (FAF) in complete (cRORA) and incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) by fluorescence lifetime imaging ophthalmology (FLIO). Methods Overall, 98 macular atrophy (MA) lesions in 42 eyes of 37 age‐related macular degeneration (AMD) patients (mean age: 80.9 ± 5.8 ...
Melih Tarhan, Daniel Meller, Martin Hammer   +2 more
wiley   +1 more source

Spotlight on reticular pseudodrusen

Clinical Ophthalmology, 2017
Alessandro Rabiolo,1 Riccardo Sacconi,1,2 Maria Vittoria Cicinelli,1 Lea Querques,1,3 Francesco Bandello,1 Giuseppe Querques1 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, 2Eye Clinic, Department of Neurological and ...
Rabiolo A, Sacconi R, Cicinelli MV, Querques L, Bandello F, Querques G   +5 more
doaj  

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part I: Methodology

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 231-246, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age‐related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation.
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part II: Results

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 247-268, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported, based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation. However, speckle noise within OCT data itself
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

Asia-Pacific Journal of Ophthalmology
Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of ...
R Theodore, Smith, Timothy W, Olsen, Victor, Chong, Judy, Kim, Martin, Hammer, Gareth, Lema, Avnish, Deobhakta, Anna, Tan, Yuehong, Tong, Katy, Tai, Yang, Fei, Emanuel, Mordechaev, Gerardo, Ledesma-Gil, Oscar, Otero-Marquez, Richard B, Rosen, Alauddin, Bhuiyan, Sobha, Sivaprasad, Philip J, Rosenfeld   +17 more
openaire   +2 more sources

Mimickers of hydroxychloroquine retinal toxicity

Clinical &Experimental Ophthalmology, Volume 52, Issue 9, Page 1003-1015, December 2024.
Abstract Hydroxychloroquine (HCQ) retinal toxicity is an important entity that can be challenging to differentiate from its mimickers. Bull's eye maculopathy is the classical presentation of HCQ retinopathy; however, its differential includes several drug‐related retinal toxicities, inherited retinal disorders, and systemic conditions with associated ...
Peter Jones, Gagan Kalra, Mayss Al‐Sheikh, Jay Chhablani   +3 more
wiley   +1 more source

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Acta Ophthalmologica, Volume 102, Issue 7, Page 759-772, November 2024.
Abstract Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent photoreceptors.
Juha M. T. Hyttinen, Ali Koskela, Janusz Blasiak, Kai Kaarniranta   +3 more
wiley   +1 more source

Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study)

Investigative Opthalmology & Visual Science, 2019
The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.The participants of the population-based Montrachet study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence ...
Gabrielle, Pierre Henry, Seydou, Alassane, Arnould, Louis, Acar, Niyazi, Devilliers, Hervé, Baudin, Florian, Ben Ghezala, Inès, Binquet, Christine, Bron, Alain Marie, Creuzot-Garcher, Catherine   +9 more
openaire   +5 more sources

Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort

Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.
Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä, Leea Siintamo, Niko Kivinen, Nicholas Abrahamsson, Vesa Aaltonen, Kai Kaarniranta   +5 more
wiley   +1 more source

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

The FASEB Journal, Volume 38, Issue 5, 15 March 2024.
The healthy RPE (left) plays a crucial role in maintaining photoreceptor health and function, in part, via the uptake (e.g., outer segment phagocytosis, plasma lipid absorption, and de novo lipid synthesis), processing (e.g., lipid oxidation and metabolism), and removal or recycling (e.g., β‐lipoproteins and HDL) of prodigious amounts of lipid. However,
Catharina R. Grubaugh, Anuradha Dhingra, Binu Prakash, Diego Montenegro, Janet R. Sparrow, Lauren L. Daniele, Christine A. Curcio, Brent A. Bell, M. Mahmood Hussain, Kathleen Boesze‐Battaglia   +9 more
wiley   +1 more source