Results 41 to 50 of about 740 (185)

A long history of dense deposit disease

BMC Ophthalmology, 2018
Background Dense Deposit Disease is a rare condition affecting the Bruch’s membrane and the glomerular basement membrane. We report the progression of the ocular manifestations over a 30 year follow up period, longer than any previous report.
Alan Cunningham, Ajay Kotagiri
doaj   +1 more source

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]

, 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David, Farsiu, Sina, Garzel, Laura, Munevar, Christian, Roberts, Jeffrey, Thomasy, Sara, Tieu, Eric, Wong, Brittany, Yiu, Glenn   +8 more
core   +2 more sources

Fructosamine-3-kinase as a potential treatment option for age-related macular degeneration [PDF]

, 2020
Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of ...
Boston, Nezahat, Bracke, Ken, De Bruyne, Sander, De Wever, Olivier, Delanghe, Joris, Himpe, Jonas, Huizing, Manon, Khelifi, Samira, Speeckaert, Marijn, Van Aken, Elisabeth, Van den Broecke, Caroline, Van Dorpe, Jo, Vral, Anne, Vrielinck, Henk   +13 more
core   +1 more source

Subretinal pigment epithelial deposition of Drusen components including hydroxyapatite in a primary cell culture model [PDF]

, 2016
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD.
Curcio, CA, Emri, E, Fearn, S, Guidry, C, Knowles, JC, Lanzirotti, A, Lengyel, I, Messinger, JD, Newville, M, Pilgrim, MG, Read, RW   +10 more
core   +1 more source

Microperimetry of Subretinal Drusenoid Deposits

Ophthalmic Research, 2013
<b><i>Purpose:</i></b> To investigate light sensitivity in eyes presenting with subretinal drusenoid deposits (SDD). <b><i>Methods:</i></b> All consecutive patients with SDD only seen between January 2012 and July 2012 were included.
Forte R, CENNAMO, GILDA, de Crecchio G, Cennamo G.   +3 more
openaire   +5 more sources

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

Journal of Extracellular Vesicles, Volume 11, Issue 12, December 2022., 2022
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific RPE cells with the Complement Factor H Y402H high‐risk polymorphism to perform a comprehensive analysis of ...
Marzena Kurzawa‐Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelytė, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al‐Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric‐Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, Majlinda Lako   +28 more
wiley   +1 more source

Deep learning identify retinal nerve fibre and choroid layers as markers of age‐related macular degeneration in the classification of macular spectral‐domain optical coherence tomography volumes

Acta Ophthalmologica, Volume 100, Issue 8, Page 937-945, December 2022., 2022
Abstract Purpose Deep learning models excel in classifying medical image data but give little insight into the areas identified as pathology. Visualization of a deep learning model’s point of interest (POI) may reveal unexpected areas associated with diseases such as age‐related macular degeneration (AMD).
Arnt‐Ole Tvenning, Stian Rikstad Hanssen, Dordi Austeng, Tora Sund Morken   +3 more
wiley   +1 more source

Differentiating drusen:Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes [PDF]

, 2016
Drusen are discussed frequently in the context of their association with age-related macular degeneration (AMD). Some types may, however, be regarded as a normal consequence of ageing; others may be observed in young age groups.
Bird, Alan, Khan, Kamron N., Khan, Rehna, Mahroo, Omar A., McKibbin, Martin, Michaelides, Michel, Mohamed, Moin D., Moore, Anthony T., Tufail, Adnan   +8 more
core   +3 more sources

Age‐related macular degeneration and myeloproliferative neoplasms – A common pathway

Acta Ophthalmologica, Volume 100, Issue S271, Page 3-35, October 2022., 2022
Summary Dansk Resumé (Danish summary) Aldersrelateret makuladegeneration (AMD) er den hyppigste årsag til uopretteligt synstab og blindhed i højindkomstlande. Det er en progredierende nethindesygdom som gradvist fører til ødelæggelse af de celler som er ansvarlige for vores centralsyn. De tidlige stadier er ofte asymptomatiske, imens senstadie AMD, som
Charlotte Liisborg
wiley   +1 more source

Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study) [PDF]

Investigative Opthalmology & Visual Science, 2019
The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.The participants of the population-based Montrachet study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence ...
Pierre‐Henry Gabrielle, Alassane Seydou, Louis Arnould, Niyazi Acar, Hervé Devilliers, Florian Baudin, Inès Ben Ghezala, Christine Binquet, Alain M. Bron, Catherine Creuzot Garcher   +9 more
openalex   +6 more sources