Results 51 to 60 of about 740 (185)

Treatment Strategy with Gene Editing for Late-onset Retinal Degeneration Caused by a Founder Variant in C1QTNF5 [PDF]

, 2023
Purpose: Genome editing is an emerging group of technologies with the potential to ameliorate dominant, monogenic human diseases such as late-onset retinal degeneration (L-ORD).
Aleman, Tomas S, Browning, Andrew C, Cideciyan, Artur V, Dhillon, Baljean, Garafalo, Alexandra V., Héon, Elise, Li, Randa T.H., Megaw, Roly, Roman, Alejandro J, Stanton, Chloe, Sumaroka, Alexander, Swider, Malgorzata, Vincent, Ajoy, Wright, Alan F.   +13 more
core   +2 more sources

ACQUIRED VITELLIFORM DETACHMENT IN PATIENTS WITH SUBRETINAL DRUSENOID DEPOSITS (RETICULAR PSEUDODRUSEN) [PDF]

Retina, 2011
To report a recently observed association of macular vitelliform detachment and subretinal drusenoid deposits (reticular pseudodrusen).Clinical and multimodal imaging data of patients with acquired vitelliform lesions in association with subretinal drusenoid deposits were reviewed.
Zweifel, S A, Spaide, R F, Yannuzzi, L A
openaire   +3 more sources

Automated detection and classification of early AMD biomarkers using deep learning [PDF]

, 2019
Age-related macular degeneration (AMD) affects millions of people and is a leading cause of blindness throughout the world. Ideally, affected individuals would be identified at an early stage before late sequelae such as outer retinal atrophy or ...
Hu Z. J., kanagasingam Y., Lindenberg S., Nassisi M., Sadda S., Saha S., Wang M.   +6 more
core   +1 more source

Assessment of a classification of age-related macular degeneration severity from the Northern Ireland Sensory Aging study using a measure of dark adaptation [PDF]

, 2022
Purpose To assess differences in rod-mediated dark adaptation (RMDA) between different grades of age-related macular degeneration (AMD) severity using an Optical Coherence Tomography (OCT)-based criterion compared to the Beckman Colour Fundus ...
Chakravarthy, U., Crabb, D. P., Graham, K. W., Higgins, B. E., Hogg, R. E., Kee, F., Montesano, G., Naskas, T., Wright, D.   +8 more
core   +2 more sources

Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits

Ophthalmology Retina, 2018
Craig Wilde, Mary Awad, Harminder S. Dua, Ravi Gandhewar, Hean-Choon Chen, Winfried M. K. Amoaku   +5 more
openalex   +3 more sources

Subretinal drusenoid deposits, age-related macular degeneration, and cardiovascular disease

Asia-Pacific Journal of Ophthalmology
Decades of studies on age-related macular degeneration (AMD), cardiovascular disease and stroke have not found consistent associations between AMD and systemic vascular disease. This study suggests that there is in fact no general relationship, but instead a strong, specific association between only the subretinal drusenoid deposit (SDD) phenotype of ...
R. Theodore Smith, Timothy W. Olsen, Victor Chong, Judy Kim, Martin Hammer, Gareth Lema, Avnish Deobhakta, Anna C. S. Tan, Yuehong Tong, Katy Tai, Fei Yang, Emanuel Mordechaev, Gerardo Ledesma‐Gil, Oscar Otero-Marquez, Richard B. Rosen, Alauddin Bhuiyan, Sobha Sivaprasad, Philip J. Rosenfeld   +17 more
openalex   +3 more sources

Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases

BMJ Open Ophthalmology, 2022
Background/aims Demonstrate that subretinal drusenoid deposits (SDDs) in age-related macular degeneration (AMD) are linked to coexistent high-risk vascular diseases (HRVDs). Methods Cross-sectional study. Two hundred AMD subjects (aged 51–100 years;
Gerardo Ledesma-Gil, Oscar Otero-Marquez, Sharmina Alauddin, Yuehong Tong, Katy Tai, Harriet Lloyd, Micaela Koci, Maria Scolaro, Cinthi Pillai, Catherine Ye, Arun Govindaiah, Alauddin Bhuiyan, Mandip S Dhamoon, Avnish Deobhakta, Gareth Lema, Jagat Narula, Richard B Rosen, Lawrence A Yannuzzi, K Bailey Freund, Roland Theodore Smith   +19 more
openaire   +2 more sources

Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation [PDF]

, 2015
PURPOSE: To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS:
Curcio, C. A., Freund, K. B., Litts, K. M., Messinger, J. D., Zhang, Y.   +4 more
core   +2 more sources

CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration [PDF]

, 2010
The causes of age-related macular degeneration (AMD) are not well understood. Due to demographic shifts in the industrialized world a growing number of people will develop AMD in the coming decades.
Auvynet, Constance, Camelo, Serge, Combadière, Christophe, Feumi, Charles, Guillonneau, Xavier, Raoul, William, Sennlaub, Florian   +6 more
core   +6 more sources

Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science, 2018
To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD).In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained twice using a dark-adapted chromatic perimeter, both ...
Rose Tan, Robyn H. Guymer, Chi D. Luu
openalex   +3 more sources