Results 61 to 70 of about 740 (185)

A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration [PDF]

, 2019
Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly in the developed world. While treatment is effective for the neovascular or "wet" form of AMD, no therapy is successful for the non-neovascular or "dry" form ...
Bowes Rickman, C, Dick, Andrew, Farrer, L A, Gorin, M B, Handa, JT, Miller, J W, Toth, C A, Ueffing, M, Zarbin, M   +8 more
core   +7 more sources

Risk factors associated with reticular pseudodrusen versus large soft drusen [PDF]

, 2014
PURPOSE: To investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen ...
Boddu, S., Freund, K. B., Lee, M. D., Marmor, M., Marsiglia, M., Smith, R. T.   +5 more
core   +3 more sources

A Case Study [PDF]

, 2023
OK Publisher Copyright: © 2023 American Academy of OphthalmologyPurpose: To investigate intraretinal neovascularization and microvascular anomalies by correlating in vivo multimodal imaging with corresponding ex vivo histology in a single patient. Design:
Balaratnasingam, Chandrakumar, Berlin, Andreas, Cabral, Diogo, Chen, Ling, Curcio, Christine A., Ferrara, Daniela, Freund, K. Bailey, Mendis, Randev, Messinger, Jeffrey D.   +8 more
core   +1 more source

A re-appraisal of pathogenic mechanisms bridging wet and dry age-related macular degeneration leads to reconsider a role for phytochemicals [PDF]

, 2020
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism?
Bertelli M., Biagioni F., Busceti C. L., Fornai F., Limanaqi F., Pinelli R., Polzella M., Scaffidi E.   +7 more
core   +2 more sources

Is Reticular Macular Disease a Choriocapillaris Perfusion Problem? [PDF]

, 2012
The etiology of reticular macular disease (RMD), a sub-phenotype of age-related macular degeneration (AMD), is controversial and has not been clarified.
A. Martillo, Miguel, Bearelly, Srilaxmi, D. Lee, Michele, Marsiglia, Marcela, Pumariega, Nicole, Smith, Theodore   +5 more
core   +5 more sources

Deep Learning‐Based Detection of Reticular Pseudodrusen in Age‐Related Macular Degeneration

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Reticular pseudodrusen (RPD) signify a critical phenotype driving vision loss in age‐related macular degeneration (AMD). This study sought to develop and externally test a deep learning (DL) model to detect RPD on optical coherence tomography (OCT) scans with expert‐level performance.
Himeesh Kumar, Yelena Bagdasarova, Scott Song, Doron G. Hickey, Amy C. Cohn, Mali Okada, Robert P. Finger, Jan H. Terheyden, Ruth E. Hogg, Pierre‐Henry Gabrielle, Louis Arnould, Maxime Jannaud, Xavier Hadoux, Peter van Wijngaarden, Carla J. Abbott, Lauren A. B. Hodgson, Roy Schwartz, Adnan Tufail, Emily Y. Chew, Cecilia S. Lee, Erica L. Fletcher, Melanie Bahlo, Brendan R. E. Ansell, Alice Pébay, Robyn H. Guymer, Aaron Y. Lee, Zhichao Wu   +26 more
wiley   +1 more source

Retinal Pigment Epithelium Degeneration Associated With Subretinal Drusenoid Deposits in Age-Related Macular Degeneration [PDF]

American Journal of Ophthalmology, 2017
To test whether increased light transmission (hypertransmission) through subretinal drusenoid deposits (SDD) into the choroid in age-related macular degeneration (AMD) represented retinal pigment epithelium (RPE) degeneration.Cross-sectional study.Nineteen eyes of 12 patients with early- to intermediate-stage AMD and 18 eyes of 12 normal subjects were ...
Xiaoyu Xu, Xing Liu, Xiaolin Wang, Mark E. Clark, Gerald McGwin, Cynthia Owsley, Christine A. Curcio, Yuhua Zhang   +7 more
openaire   +2 more sources

Spatial Dissociation of Subretinal Drusenoid Deposits and Impaired Scotopic and Mesopic Sensitivity in AMD

Investigative Opthalmology & Visual Science, 2022
Subretinal drusenoid deposits (SDD) first appear in the rod-rich perifovea and can extend to the cone-rich fovea. To refine the spatial relationship of visual dysfunction with SDD burden, we determined the topography of mesopic and scotopic light sensitivity in participants with non-neovascular AMD with and without SDD.Thirty-three subjects were ...
Zhang, Yuhua, Sadda, SriniVas R., Sarraf, David, Swain, Thomas A., Clark, Mark E., Sloan, Kenneth R., Warriner, William E., Owsley, Cynthia, Curcio, Christine A.   +8 more
openaire   +2 more sources

Ten‐Year Incidence, Risk Factors and Progression Rate of Macular Atrophy in Neovascular Age‐Related Macular Degeneration

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To evaluate the 10‐year cumulative incidence, progression rates, and risk factors for macular atrophy (MA) in neovascular age‐related macular degeneration (nAMD) patients receiving long‐term anti‐vascular endothelial growth factor (VEGF) therapy.
Francesco Romano, Marco Casaluci, Antonio Valastro, Matteo Airaldi, Paolo Milella, Francesco Pozzo Giuffrida, Elisa Cozzi, Andrea Aretti, Kelvin YC Teo, Chui Ming Gemmy Cheung, Marco Nassisi, Francesco Viola, Giovanni Staurenghi, Alessandro Invernizzi   +13 more
wiley   +1 more source

Visual Function Assessment in Geographic Atrophy: A Review

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Geographic atrophy (GA) causes significant vision impairment and reduction in vision‐related quality of life. Fundus autofluorescence (FAF) is the gold standard of structural assessment of GA but is a surrogate marker for vision loss, which can be assessed by tests of visual function and functional vision.
Ye Li, Lauren N. Ayton, Adrian T. Fung
wiley   +1 more source