Results 71 to 80 of about 740 (185)

Fundus autofluorescence lifetimes in age‐related macular degeneration versus healthy controls in a pseudophakic population

Acta Ophthalmologica, Volume 103, Issue 6, Page e394-e400, September 2025.
Abstract Purpose To check whether prolonged fundus autofluorescence (FAF) lifetimes in age‐related macular degeneration (AMD) could be an artefact resulting from lens fluorescence. Methods Fluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in pseudophakic intermediate AMD as well as healthy controls. The median values of FAF lifetimes in
Jana Oertel, Dominik Fischer, Melih Tarhan, Daniel Meller, Martin Hammer   +4 more
wiley   +1 more source

‘EarlyAMDRate’: A grading instrument for OCT‐based assessment of early lesions caused by age‐related macular degeneration

Acta Ophthalmologica, Volume 103, Issue 5, Page e318-e331, August 2025.
Abstract Background and Objectives Long before any signs of age‐related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina.
Marcus Wagner, Thomas Peschel, Carla J. Leutloff, Franziska G. Rauscher   +3 more
wiley   +1 more source

The Ercc1−/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration

Aging Cell, Volume 24, Issue 3, March 2025.
Spontaneous endogenous DNA damage drives key hallmarks of age‐related retinal degeneration, including visual impairment, photoreceptor cell loss, dysmorphic RPE, mitochondrial dysfunction, and cellular senescence. Therefore, Ercc1−/Δ mice represent a valuable model for further mechanistic studies on age‐related retinal degeneration and for rapid ...
Akilavalli Narasimhan, Seok Hong Min, Laura L. Johnson, Heidi Roehrich, William Cho, Tracy K. Her, Caeden Windschitl, Ryan D. O'Kelly, Luise Angelini, Matthew J. Yousefzadeh, Linda K. McLoon, William W. Hauswirth, Paul D. Robbins, Dorota Skowronska‐Krawczyk, Laura J. Niedernhofer   +14 more
wiley   +1 more source

Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and enhanced-depth imaging optical coherence tomography in eyes with reticular pseudodrusen and soft drusen [PDF]

, 2021
Background: To assess the vascularity of choriocapillaris and structural choroidal differences in eyes with reticular pseudodrusen (RPD) and soft drusen.
Batıoğlu, Figen, Demirel, Sibel, Temel, Emine, Yanık, Özge, Özcan, Gökçen, Özmert, Emin   +5 more
core   +1 more source

Hyperautofluorescent material inside areas of macular atrophy may reveal non‐lipofuscin fluorophores in late stage AMD

Acta Ophthalmologica, Volume 103, Issue 1, Page e66-e75, February 2025.
Abstract Purpose To characterize fundus autofluorescence (FAF) in complete (cRORA) and incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) by fluorescence lifetime imaging ophthalmology (FLIO). Methods Overall, 98 macular atrophy (MA) lesions in 42 eyes of 37 age‐related macular degeneration (AMD) patients (mean age: 80.9 ± 5.8 ...
Melih Tarhan, Daniel Meller, Martin Hammer   +2 more
wiley   +1 more source

Multimodal imaging of retinal pigment epithelial detachments in patients with C3 glomerulopathy: case report and review of the literature. [PDF]

, 2017
To describe the optical coherence tomography angiograhy (OCTA) of drusenoid pigment epithelial detachments (PEDs) in a woman affected by Complement 3 (C3) glomerulopathy, which represents a spectrum of glomerular diseases characterized on fluorescent ...
Dirani, A., Guex-Crosier, Y., Halabi, G., Halfon, M., Kheir, V., Venetz, J.P.   +5 more
core   +2 more sources

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part I: Methodology

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 231-246, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age‐related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation.
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part II: Results

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 247-268, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported, based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation. However, speckle noise within OCT data itself
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Mimickers of hydroxychloroquine retinal toxicity

Clinical &Experimental Ophthalmology, Volume 52, Issue 9, Page 1003-1015, December 2024.
Abstract Hydroxychloroquine (HCQ) retinal toxicity is an important entity that can be challenging to differentiate from its mimickers. Bull's eye maculopathy is the classical presentation of HCQ retinopathy; however, its differential includes several drug‐related retinal toxicities, inherited retinal disorders, and systemic conditions with associated ...
Peter Jones, Gagan Kalra, Mayss Al‐Sheikh, Jay Chhablani   +3 more
wiley   +1 more source

Bilateral macular drusen in acquired partial lipodystrophy with type 2 membranoproliferative glomerulonephritis [PDF]

, 2021
A 35-year-old woman with acquired partial lipodystrophy (PLD) and features of type 2 membranoproliferative glomerulonephritis (MPGN-II), presented with difficulty in her fine detailed vision over the past year.
Chan, HW, Moosajee, M, Stears, A, Tanner, A   +3 more
core