Results 81 to 90 of about 740 (185)
Autophagy in drusen biogenesis secondary to age‐related macular degeneration
Acta Ophthalmologica, Volume 102, Issue 7, Page 759-772, November 2024.Abstract Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent photoreceptors.
Juha M. T. Hyttinen +3 more
wiley +1 more source
Mtor-Initiated Metabolic Switch and Degeneration in the Retinal Pigment Epithelium [PDF]
, 2020 The retinal pigment epithelium (RPE) is a particularly vulnerable tissue to age-dependent degeneration. Over the life span, the RPE develops an expanded endo-lysosomal compartment to maintain the high efficiency of phagocytosis and degradation of ...
Cai, Jiyang +8 more
core +2 more sources
Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä +5 more
wiley +1 more source
Choriocapillaris flow impairment predicts the development and enlargement of drusen [PDF]
, 2019 Purpose: To evaluate the choriocapillaris flow in regions of enlarged or new incident drusen in patients with early and intermediate age-related macular degeneration (AMD).
M. Nassisi +3 more
core +1 more source
The FASEB Journal, Volume 38, Issue 5, 15 March 2024.The healthy RPE (left) plays a crucial role in maintaining photoreceptor health and function, in part, via the uptake (e.g., outer segment phagocytosis, plasma lipid absorption, and de novo lipid synthesis), processing (e.g., lipid oxidation and metabolism), and removal or recycling (e.g., β‐lipoproteins and HDL) of prodigious amounts of lipid. However,
Catharina R. Grubaugh +9 more
wiley +1 more source
Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins [PDF]
, 2020 Background Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...
Aramburu, Ana +13 more
core +2 more sources
Association of Reticular Pseudodrusen and Early Onset Drusen [PDF]
, 2013 Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes)
Benjamin Wolff +5 more
core +2 more sources
3D Curvelet-Based Segmentation and Quantification of Drusen in Optical Coherence Tomography Images [PDF]
, 2017 Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used interferometric diagnostic technique in ophthalmology that provides novel in vivo information of depth-resolved inner and outer retinal structures.
A. M. Dehnavi, H. Rabbani, M. Esmaeili
core +2 more sources
Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss [PDF]
, 2018 Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.
Apte, Rajendra S +10 more
core +1 more source
Use of Composite End Points in Early and Intermediate Age-Related Macular Degeneration Clinical Trials: State-of-the-Art and Future Directions [PDF]
, 2021 The slow progression of early AMD stages to advanced AMD requires the use of surrogate endpoints in clinical trials. The use of combined endpoints may allow for shorter and smaller trials due to increased precision.
Behning, C +13 more
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