Results 91 to 100 of about 1,783 (192)

Fundus autofluorescence lifetimes in age‐related macular degeneration versus healthy controls in a pseudophakic population

Acta Ophthalmologica, Volume 103, Issue 6, Page e394-e400, September 2025.
Abstract Purpose To check whether prolonged fundus autofluorescence (FAF) lifetimes in age‐related macular degeneration (AMD) could be an artefact resulting from lens fluorescence. Methods Fluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in pseudophakic intermediate AMD as well as healthy controls. The median values of FAF lifetimes in
Jana Oertel, Dominik Fischer, Melih Tarhan, Daniel Meller, Martin Hammer   +4 more
wiley   +1 more source

Clinical Characteristics of Neovascular Age-Related Macular Degeneration without Typical Drusen

Journal of Ophthalmology, 2021
Purpose. To evaluate the clinical characteristics of neovascular age-related macular degeneration (nAMD) patients without typical drusen. Methods. We retrospectively studied 165 eyes in 165 patients with treatment-naïve nAMD, including typical AMD and ...
Hiroyuki Kamao, Katsutoshi Goto, Kento Matsuno, Kenichi Mizukawa, Atsushi Miki, Junichi Kiryu   +5 more
doaj   +1 more source

Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data: Consensus on Neovascular Age-Related Macular Degeneration Nomenclature Study Group [PDF]

, 2020
© 2019 American Academy of Ophthalmology Purpose: To establish a process to evaluate and standardize a state-of-the-art nomenclature for reporting neovascular age-related macular degeneration (AMD) data. Design: Consensus meeting.
+25 additional authors, Chakravarthy, U., Freund, K. B., Fujimoto, J., Jaffe, G. J., Sadda, S. R., Sarraf, D., Spaide, R. F., Staurenghi, G., Waheed, N. K., Yannuzzi, L. A.   +10 more
core   +2 more sources

‘EarlyAMDRate’: A grading instrument for OCT‐based assessment of early lesions caused by age‐related macular degeneration

Acta Ophthalmologica, Volume 103, Issue 5, Page e318-e331, August 2025.
Abstract Background and Objectives Long before any signs of age‐related macular degeneration (AMD) become clinically noticeable, the disease starts with accumulation of deposits of extracellular debris and formation of lesions within the outermost layers of the retina.
Marcus Wagner, Thomas Peschel, Carla J. Leutloff, Franziska G. Rauscher   +3 more
wiley   +1 more source

The Ercc1−/Δ mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration

Aging Cell, Volume 24, Issue 3, March 2025.
Spontaneous endogenous DNA damage drives key hallmarks of age‐related retinal degeneration, including visual impairment, photoreceptor cell loss, dysmorphic RPE, mitochondrial dysfunction, and cellular senescence. Therefore, Ercc1−/Δ mice represent a valuable model for further mechanistic studies on age‐related retinal degeneration and for rapid ...
Akilavalli Narasimhan, Seok Hong Min, Laura L. Johnson, Heidi Roehrich, William Cho, Tracy K. Her, Caeden Windschitl, Ryan D. O'Kelly, Luise Angelini, Matthew J. Yousefzadeh, Linda K. McLoon, William W. Hauswirth, Paul D. Robbins, Dorota Skowronska‐Krawczyk, Laura J. Niedernhofer   +14 more
wiley   +1 more source

Is Reticular Macular Disease a Choriocapillaris Perfusion Problem? [PDF]

, 2012
The etiology of reticular macular disease (RMD), a sub-phenotype of age-related macular degeneration (AMD), is controversial and has not been clarified.
A. Martillo, Miguel, Bearelly, Srilaxmi, D. Lee, Michele, Marsiglia, Marcela, Pumariega, Nicole, Smith, Theodore   +5 more
core   +5 more sources

Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium

Journal of Lipid Research, 2018
Cholesterol-containing soft drusen and subretinal drusenoid deposits (SDDs) occur at the basolateral and apical side of the retinal pigment epithelium (RPE), respectively, in the chorioretina and are independent risk factors for late age-related macular ...
Nicholas N. Lyssenko, Naqi Haider, Antonino Picataggi, Eleonora Cipollari, Wanzhen Jiao, Michael C. Phillips, Daniel J. Rader, Venkata Ramana Murthy Chavali   +7 more
doaj   +1 more source

Automated detection and classification of early AMD biomarkers using deep learning [PDF]

, 2019
Age-related macular degeneration (AMD) affects millions of people and is a leading cause of blindness throughout the world. Ideally, affected individuals would be identified at an early stage before late sequelae such as outer retinal atrophy or ...
Hu Z. J., kanagasingam Y., Lindenberg S., Nassisi M., Sadda S., Saha S., Wang M.   +6 more
core   +1 more source

Hyperautofluorescent material inside areas of macular atrophy may reveal non‐lipofuscin fluorophores in late stage AMD

Acta Ophthalmologica, Volume 103, Issue 1, Page e66-e75, February 2025.
Abstract Purpose To characterize fundus autofluorescence (FAF) in complete (cRORA) and incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) by fluorescence lifetime imaging ophthalmology (FLIO). Methods Overall, 98 macular atrophy (MA) lesions in 42 eyes of 37 age‐related macular degeneration (AMD) patients (mean age: 80.9 ± 5.8 ...
Melih Tarhan, Daniel Meller, Martin Hammer   +2 more
wiley   +1 more source

Chronic Central Serous Chorioretinopathy in Elderly Subjects: Structure and Blood Flow Characteristics of Retina and Choroid

Ophthalmology and Therapy, 2023
Introduction With advancements in imaging technology, researchers have been able to identify more distinctive imaging features of central serous chorioretinopathy (CSC).
Pei Liu, Haixin Fang, Guangqi An, Bo Jin, Chenyu Lu, Shu Li, Fan Yang, Liping Du, Xuemin Jin   +8 more
doaj   +1 more source