Results 91 to 100 of about 1,714 (199)

Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods

BMC Ophthalmology, 2020
Background Age-related macular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and globally, is a disease of the photoreceptor support system involving the retinal pigment epithelium (RPE), Bruch’s membrane, and
Christine A. Curcio, Gerald McGwin, Srinivas R. Sadda, Zhihong Hu, Mark E. Clark, Kenneth R. Sloan, Thomas Swain, Jason N. Crosson, Cynthia Owsley   +8 more
doaj   +1 more source

Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation [PDF]

, 2015
PURPOSE: To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS:
Curcio, C. A., Freund, K. B., Litts, K. M., Messinger, J. D., Zhang, Y.   +4 more
core   +2 more sources

Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort

Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.
Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä, Leea Siintamo, Niko Kivinen, Nicholas Abrahamsson, Vesa Aaltonen, Kai Kaarniranta   +5 more
wiley   +1 more source

Subretinal Drusenoid Deposits in the Elderly in a Population-Based Study (the Montrachet Study)

Investigative Opthalmology & Visual Science, 2019
The aim of this study was to investigate the prevalence of subretinal drusenoid deposits (SDD) and to identify associated factors in an elderly population.The participants of the population-based Montrachet study underwent an exhaustive ophthalmologic examination, including color fundus photography and macular spectral domain-optical coherence ...
Gabrielle, Pierre Henry, Seydou, Alassane, Arnould, Louis, Acar, Niyazi, Devilliers, Hervé, Baudin, Florian, Ben Ghezala, Inès, Binquet, Christine, Bron, Alain Marie, Creuzot-Garcher, Catherine   +9 more
openaire   +5 more sources

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

The FASEB Journal, Volume 38, Issue 5, 15 March 2024.
The healthy RPE (left) plays a crucial role in maintaining photoreceptor health and function, in part, via the uptake (e.g., outer segment phagocytosis, plasma lipid absorption, and de novo lipid synthesis), processing (e.g., lipid oxidation and metabolism), and removal or recycling (e.g., β‐lipoproteins and HDL) of prodigious amounts of lipid. However,
Catharina R. Grubaugh, Anuradha Dhingra, Binu Prakash, Diego Montenegro, Janet R. Sparrow, Lauren L. Daniele, Christine A. Curcio, Brent A. Bell, M. Mahmood Hussain, Kathleen Boesze‐Battaglia   +9 more
wiley   +1 more source

Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice

BMC Neuroscience, 2012
Background Intensive light exposure and beta-amyloid (Aβ) aggregates have been known as a risk factor for macular degeneration and an important component in the pathologic drusen structure involved in this disorder, respectively.
Dong Zhizhang, Li Juan, Leng Yunxia, Sun Xuerong, Hu Huiling, He Yuan, Tan Zhiqun, Ge Jian   +7 more
doaj   +1 more source

An Evaluation of a Battery of Functional and Structural Tests as Predictors of Likely Risk of Progression of Age-Related Macular Degeneration. [PDF]

, 2018
Purpose: To evaluate the ability of visual function and structural tests to identify the likely risk of progression from early/intermediate to advanced AMD, using the Age-Related Eye Disease Study (AREDS) simplified scale as a surrogate for risk of ...
Bailey, C., Binns, A. M., Margrain, T. H., Robinson, D. G.   +3 more
core   +3 more sources

A re-appraisal of pathogenic mechanisms bridging wet and dry age-related macular degeneration leads to reconsider a role for phytochemicals [PDF]

, 2020
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism?
Bertelli M., Biagioni F., Busceti C. L., Fornai F., Limanaqi F., Pinelli R., Polzella M., Scaffidi E.   +7 more
core   +2 more sources

Pathology, multimodal imaging and clinical significance of age-related fundus deposits

Yanke Xuebao
Fundus aging is a key factor and pathological basis for the development and progression of age-related macular degeneration (AMD), which is histopathologically characterized by choroidal capillary atrophy, Bruch’s membrane(BrM) thickening, and ...
CAI Jinyu, JIANG Yanmei, CHEN Ling
doaj   +1 more source

Pachydrusen in Indian population: A hospital-based study

Indian Journal of Ophthalmology, 2019
Purpose: To report the prevalence of pachydrusen in Indian population and their characteristics in relation to subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI) in comparison to eyes with soft drusen and subretinal drusenoid ...
Sumit Randhir Singh, Avadhesh Oli, Sashwanthi Mohan, Abhilash Goud, Mohammed A Rasheed, Kiran K Vupparaboina, Jay K Chhablani   +6 more
doaj   +1 more source