PLoS ONE, 2020 ObjectiveTo investigate the thicknesses of the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) of the fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD).MethodsA total of 107 ...
Seong Eun Lee +5 more
doaj +1 more source
Assessing Reliability and Agreement in Topographic Measurement of Reticular Pseudodrusen Area: A Multimodal Imaging Approach [PDF]
Purpose: This study aims to assess the reliability and agreement of fundus autofluorescence (FAF), near-infrared reflectance (NIR), and a combination of NIR and dense structural optical coherence tomography (OCT) scans (OCT+NIR) in delineating the areas ...
Cozzi, Mariano +5 more
core +1 more source
Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration. [PDF]
, 2021 To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals.
Bird, A +4 more
core
Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography [PDF]
, 2020 Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined that algorithm so that its accuracy is increased.
Finger, R.P. +7 more
core +1 more source
Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss [PDF]
, 2018 Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.
Apte, Rajendra S +10 more
core +1 more source
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion [PDF]
Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic and genotoxic stresses, convergently acting through
Apte, Rajendra S +12 more
core +2 more sources
RETINAL ANGIOMATOUS PROLIFERATION: A Quantitative Analysis of the Fundoscopic Features of the Fellow Eye [PDF]
, 2015 PURPOSE: To quantitatively analyze and compare the fundoscopic features between fellow eyes of retinal angiomatous proliferation and typical exudative age-related macular degeneration and to identify possible predictors of neovascularization. METHODS:
Costa, MA +6 more
core +1 more source
Subretinal Drusenoid Deposits Revealed by Color SLO and Retro-Mode Imaging [PDF]
Ophthalmology, 2021 Giulia Corradetti +2 more
openaire +2 more sources
Longitudinal changes in outer nuclear layer thickness in soft drusen and reticular pseudodrusen [PDF]
, 2019 This is the peer reviewed version of the following article: Ramon, C. , Cardona, G. , Biarnés, M. , Ferraro, L. L. and Monés, J. (2019), Longitudinal changes in outer nuclear layer thickness in soft drusen and reticular pseudodrusen. Clin Exp Optom, 102:
Biarnés, Marc +4 more
core +2 more sources
Ten-year follow-up of fellow eyes in patients with unilateral naive exudative age-related macular degeneration [PDF]
Purpose: To determine the 10-year morphologic outcomes and identify potential risk factors of exudative age-related macular degeneration (AMD) in the fellow eyes (FEs) in patients with naive exudative AMD.
Casaluci, Marco +11 more
core +1 more source