Results 101 to 110 of about 1,783 (192)

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part I: Methodology

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 231-246, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age‐related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation.
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Extracting full information from OCT scans—signs of early age‐related macular degeneration within inner retinal layers by local neighbourhood statistics. Part II: Results

Ophthalmic and Physiological Optics, Volume 45, Issue 1, Page 247-268, January 2025.
Abstract Background and Objectives Associations between the occurrence of early age related macular degeneration (AMD) and alterations in retinal layer thicknesses have been reported, based on classical processing of optical coherence tomography (OCT) data by noise removal and subsequent image segmentation. However, speckle noise within OCT data itself
Marcus Wagner, Julia Sommerer, Franziska G. Rauscher   +2 more
wiley   +1 more source

Mimickers of hydroxychloroquine retinal toxicity

Clinical &Experimental Ophthalmology, Volume 52, Issue 9, Page 1003-1015, December 2024.
Abstract Hydroxychloroquine (HCQ) retinal toxicity is an important entity that can be challenging to differentiate from its mimickers. Bull's eye maculopathy is the classical presentation of HCQ retinopathy; however, its differential includes several drug‐related retinal toxicities, inherited retinal disorders, and systemic conditions with associated ...
Peter Jones, Gagan Kalra, Mayss Al‐Sheikh, Jay Chhablani   +3 more
wiley   +1 more source

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Acta Ophthalmologica, Volume 102, Issue 7, Page 759-772, November 2024.
Abstract Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent photoreceptors.
Juha M. T. Hyttinen, Ali Koskela, Janusz Blasiak, Kai Kaarniranta   +3 more
wiley   +1 more source

Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods

BMC Ophthalmology, 2020
Background Age-related macular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and globally, is a disease of the photoreceptor support system involving the retinal pigment epithelium (RPE), Bruch’s membrane, and
Christine A. Curcio, Gerald McGwin, Srinivas R. Sadda, Zhihong Hu, Mark E. Clark, Kenneth R. Sloan, Thomas Swain, Jason N. Crosson, Cynthia Owsley   +8 more
doaj   +1 more source

A re-appraisal of pathogenic mechanisms bridging wet and dry age-related macular degeneration leads to reconsider a role for phytochemicals [PDF]

, 2020
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for dry and wet variants, or do they stem from common metabolic alterations? Where shall we look for altered metabolism?
Bertelli M., Biagioni F., Busceti C. L., Fornai F., Limanaqi F., Pinelli R., Polzella M., Scaffidi E.   +7 more
core   +2 more sources

Analysis of prognostic and predictive factors in neovascular age‐related macular degeneration Kuopio cohort

Acta Ophthalmologica, Volume 102, Issue 6, Page 703-713, September 2024.
Abstract Purpose The aim of the study was to explore factors affecting the progression of neovascular age‐related macular degeneration (nAMD) and identify predictive factors that can estimate the duration of intravitreal treatments. Methods This retrospective real‐world study included 421 nAMD patients treated at the Kuopio University Hospital during ...
Hanna Heloterä, Leea Siintamo, Niko Kivinen, Nicholas Abrahamsson, Vesa Aaltonen, Kai Kaarniranta   +5 more
wiley   +1 more source

Inner Segment Remodeling and Mitochondrial Translocation in Cone Photoreceptors in Age-Related Macular Degeneration With Outer Retinal Tubulation [PDF]

, 2015
PURPOSE: To quantify impressions of mitochondrial translocation in degenerating cones and to determine the nature of accumulated material in the subretinal space with apparent inner segment (IS)-like features by examining cone IS ultrastructure. METHODS:
Curcio, C. A., Freund, K. B., Litts, K. M., Messinger, J. D., Zhang, Y.   +4 more
core   +2 more sources

Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function

The FASEB Journal, Volume 38, Issue 5, 15 March 2024.
The healthy RPE (left) plays a crucial role in maintaining photoreceptor health and function, in part, via the uptake (e.g., outer segment phagocytosis, plasma lipid absorption, and de novo lipid synthesis), processing (e.g., lipid oxidation and metabolism), and removal or recycling (e.g., β‐lipoproteins and HDL) of prodigious amounts of lipid. However,
Catharina R. Grubaugh, Anuradha Dhingra, Binu Prakash, Diego Montenegro, Janet R. Sparrow, Lauren L. Daniele, Christine A. Curcio, Brent A. Bell, M. Mahmood Hussain, Kathleen Boesze‐Battaglia   +9 more
wiley   +1 more source

Cyclic intensive light exposure induces retinal lesions similar to age-related macular degeneration in APPswe/PS1 bigenic mice

BMC Neuroscience, 2012
Background Intensive light exposure and beta-amyloid (Aβ) aggregates have been known as a risk factor for macular degeneration and an important component in the pathologic drusen structure involved in this disorder, respectively.
Dong Zhizhang, Li Juan, Leng Yunxia, Sun Xuerong, Hu Huiling, He Yuan, Tan Zhiqun, Ge Jian   +7 more
doaj   +1 more source