Pachydrusen in Indian population: A hospital-based study
Indian Journal of Ophthalmology, 2019 Purpose: To report the prevalence of pachydrusen in Indian population and their characteristics in relation to subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI) in comparison to eyes with soft drusen and subretinal drusenoid ...
Sumit Randhir Singh +6 more
doaj +1 more source
PLoS ONE, 2020 ObjectiveTo investigate the thicknesses of the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) of the fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD).MethodsA total of 107 ...
Seong Eun Lee +5 more
doaj +1 more source
Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration. [PDF]
, 2021 To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals.
Bird, A +4 more
core
Replication and Refinement of an Algorithm for Automated Drusen Segmentation on Optical Coherence Tomography [PDF]
, 2020 Here, we investigate the extent to which re-implementing a previously published algorithm for OCT-based drusen quantification permits replicating the reported accuracy on an independent dataset. We refined that algorithm so that its accuracy is increased.
Finger, R.P. +7 more
core +1 more source
Pathology, multimodal imaging and clinical significance of age-related fundus deposits
Yanke XuebaoFundus aging is a key factor and pathological basis for the development and progression of age-related macular degeneration (AMD), which is histopathologically characterized by choroidal capillary atrophy, Bruch’s membrane(BrM) thickening, and ...
CAI Jinyu, JIANG Yanmei, CHEN Ling
doaj +1 more source
Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss [PDF]
, 2018 Advanced age-related macular degeneration (AMD), the leading cause of blindness among people over 50 years of age, is characterized by atrophic neurodegeneration or pathologic angiogenesis.
Apte, Rajendra S +10 more
core +1 more source
Assessing Reliability and Agreement in Topographic Measurement of Reticular Pseudodrusen Area: A Multimodal Imaging Approach [PDF]
Purpose: This study aims to assess the reliability and agreement of fundus autofluorescence (FAF), near-infrared reflectance (NIR), and a combination of NIR and dense structural optical coherence tomography (OCT) scans (OCT+NIR) in delineating the areas ...
Cozzi, Mariano +5 more
core +1 more source
Pachychoroid neovasculopathy and age-related macular degeneration. [PDF]
, 2015 Pachychoroid neovasculopathy is a recently proposed clinical entity of choroidal neovascularization (CNV). As it often masquerades as neovascular age-related macular degeneration (AMD), it is currently controversial whether pachychoroid neovasculopathy ...
Akagi-Kurashige, Yumiko +11 more
core +1 more source
LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion [PDF]
Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic and genotoxic stresses, convergently acting through
Apte, Rajendra S +12 more
core +2 more sources
Spotlight on reticular pseudodrusen [PDF]
, 2017 Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous ...
Bandello, Francesco +5 more
core +2 more sources