Results 51 to 60 of about 1,783 (192)

In Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques. [PDF]

, 2017
Nonhuman primates are the only mammals to possess a true macula similar to humans, and spontaneously develop drusenoid lesions which are hallmarks of age-related macular degeneration (AMD).
Cunefare, David, Farsiu, Sina, Garzel, Laura, Munevar, Christian, Roberts, Jeffrey, Thomasy, Sara, Tieu, Eric, Wong, Brittany, Yiu, Glenn   +8 more
core   +2 more sources

Fructosamine-3-kinase as a potential treatment option for age-related macular degeneration [PDF]

, 2020
Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of ...
Boston, Nezahat, Bracke, Ken, De Bruyne, Sander, De Wever, Olivier, Delanghe, Joris, Himpe, Jonas, Huizing, Manon, Khelifi, Samira, Speeckaert, Marijn, Van Aken, Elisabeth, Van den Broecke, Caroline, Van Dorpe, Jo, Vral, Anne, Vrielinck, Henk   +13 more
core   +1 more source

Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen [PDF]

, 2017
Purpose: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies.
Baljean Dhillon, Buitendijk, Chan, Cheng, Cymerman, David E Newby, Domalpally, Edwin JR van Beek, Emanuele Trucco, Enrico Pellegrini, Finger, Frank Kee, Gareth J McKay, Gavin Robertson, Gliem, Gliem, Ian S Young, Leisy, Michelle C Williams, Nicola B Quinn, Pellegrini, Rachel V McCarter, Rastogi, Ruth E Hogg, Tom J MacGillivray, Tunde Peto, Usha Chakravarthy, Wu   +27 more
core   +4 more sources

Retinal progression biomarkers of early and intermediate age-related macular degeneration [PDF]

, 2021
Funding Information: Funding: This work was supported by Fundação para a Ciência e Tecnologia project PTDC/MED-PAT/30385/2017 and iNOVA4Health-UIDB/04462/2020, a program financially supported by Fun-dação para a Ciência e Tecnologia/Ministério da ...
Carneiro, Ângela, Flores, Rita, Seabra, Miguel C., Tenreiro, Sandra   +3 more
core   +2 more sources

Microperimetry of Subretinal Drusenoid Deposits

Ophthalmic Research, 2013
<b><i>Purpose:</i></b> To investigate light sensitivity in eyes presenting with subretinal drusenoid deposits (SDD). <b><i>Methods:</i></b> All consecutive patients with SDD only seen between January 2012 and July 2012 were included.
Forte R, CENNAMO, GILDA, de Crecchio G, Cennamo G.   +3 more
openaire   +5 more sources

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

Journal of Extracellular Vesicles, Volume 11, Issue 12, December 2022., 2022
Abstract Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient‐specific RPE cells with the Complement Factor H Y402H high‐risk polymorphism to perform a comprehensive analysis of ...
Marzena Kurzawa‐Akanbi, Phillip Whitfield, Florence Burté, Pietro Maria Bertelli, Varun Pathak, Mary Doherty, Birthe Hilgen, Lina Gliaudelytė, Mark Platt, Rachel Queen, Jonathan Coxhead, Andrew Porter, Maria Öberg, Daniela Fabrikova, Tracey Davey, Chia Shyan Beh, Maria Georgiou, Joseph Collin, Veronika Boczonadi, Anetta Härtlova, Michael Taggart, Jumana Al‐Aama, Viktor I Korolchuk, Christopher M Morris, Jasenka Guduric‐Fuchs, David H Steel, Reinhold J Medina, Lyle Armstrong, Majlinda Lako   +28 more
wiley   +1 more source

Reticular Pseudodrusen: Interreader Agreement of Evaluation on OCT Imaging in Age-Related Macular Degeneration

Ophthalmology Science, 2023
Purpose: To determine the interreader agreement for reticular pseudodrusen (RPD) assessment on combined infrared reflectance (IR) and OCT imaging in the early stages of age-related macular degeneration across a range of different criteria to define their
Zhichao Wu, BAppSc(Optom), PhD, Steffen Schmitz-Valckenberg, MD, Barbara A. Blodi, MD, Frank G. Holz, MD, Glenn J. Jaffe, MD, Sandra Liakopoulos, MD, Srinivas R. Sadda, MD, Mari Bonse, BSc, Tyler Brown, COA, John Choong, BS, Bailey Clifton, COA, Giulia Corradetti, MD, Federico Corvi, MD, Andrew C. Dieu, MD, Vivienne Dooling, MD, Jeong W. Pak, PhD, Marlene Saßmannshausen, MD, Cindy Skalak, RN, COT, Sarah Thiele, MD, Robyn H. Guymer, MBBS, PhD   +19 more
doaj   +1 more source

Macular Atrophy Development and Subretinal Drusenoid Deposits in Anti-Vascular Endothelial Growth Factor Treated Age-Related Macular Degeneration. [PDF]

Invest Ophthalmol Vis Sci, 2017
Zarubina AV, Gal-Or O, Huisingh CE, Owsley C, Freund KB.   +4 more
europepmc   +3 more sources

Subretinal pigment epithelial deposition of Drusen components including hydroxyapatite in a primary cell culture model [PDF]

, 2016
Purpose: Extracellular deposits containing hydroxyapatite, lipids, proteins, and trace metals that form between the basal lamina of the RPE and the inner collagenous layer of Bruch's membrane are hallmarks of early AMD.
Curcio, CA, Emri, E, Fearn, S, Guidry, C, Knowles, JC, Lanzirotti, A, Lengyel, I, Messinger, JD, Newville, M, Pilgrim, MG, Read, RW   +10 more
core   +1 more source

Deep learning identify retinal nerve fibre and choroid layers as markers of age‐related macular degeneration in the classification of macular spectral‐domain optical coherence tomography volumes

Acta Ophthalmologica, Volume 100, Issue 8, Page 937-945, December 2022., 2022
Abstract Purpose Deep learning models excel in classifying medical image data but give little insight into the areas identified as pathology. Visualization of a deep learning model’s point of interest (POI) may reveal unexpected areas associated with diseases such as age‐related macular degeneration (AMD).
Arnt‐Ole Tvenning, Stian Rikstad Hanssen, Dordi Austeng, Tora Sund Morken   +3 more
wiley   +1 more source