Results 61 to 70 of about 1,714 (199)

SUBRETINAL DRUSENOID DEPOSIT IN AGE-RELATED MACULAR DEGENERATION

Retina, 2020
Purpose: To clarify the role of subretinal drusenoid deposits (SDD; pseudodrusen) in the progression of age-related macular degeneration through high-resolution histology. Methods: In 33 eyes of 32 donors (early age-related macular degeneration, n = 15; geographic atrophy, n = 9 ...
Ling, Chen, Jeffrey D, Messinger, Yuhua, Zhang, Richard F, Spaide, K Bailey, Freund, Christine A, Curcio   +5 more
openaire   +3 more sources

Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

Biomedical Optics Express, 2014
Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded ...
Alexander, Meadway, Xiaolin, Wang, Christine A, Curcio, Yuhua, Zhang   +3 more
openaire   +2 more sources

Biometrics, Impact, and Significance of Basal Linear Deposit and Subretinal Drusenoid Deposit in Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science, 2021
Basal linear deposit (BLinD) is a thin layer of soft drusen material. To elucidate the biology of extracellular deposits conferring age-related macular degeneration (AMD) progression risk and inform multimodal clinical imaging based on optical coherence tomography (OCT), we examined lipid content and regional prevalence of BLinD, soft drusen, pre-BLinD,
Chen, Ling, Messinger, Jeffrey D, Kar, Deepayan, Duncan, Jacque L, Curcio, Christine A   +4 more
openaire   +4 more sources

Macular Atrophy of the Retinal Pigment Epithelium in Patients with Neovascular Age-Related Macular Degeneration: What is the Link? Part I: A Review of Disease Characterization and Morphological Associations

Ophthalmology and Therapy, 2019
Introduction The purpose of this review was to explore the potential link between macular atrophy (MA) of the retinal pigment epithelium in patients with neovascular age-related macular degeneration (nAMD) with the disease characteristics and ...
Mania Horani, Sajjad Mahmood, Tariq M. Aslam   +2 more
doaj   +1 more source

Retinal Pigment Epithelium Degeneration Associated With Subretinal Drusenoid Deposits in Age-Related Macular Degeneration. [PDF]

Am J Ophthalmol, 2017
To test whether increased light transmission (hypertransmission) through subretinal drusenoid deposits (SDD) into the choroid in age-related macular degeneration (AMD) represented retinal pigment epithelium (RPE) degeneration.Cross-sectional study.Nineteen eyes of 12 patients with early- to intermediate-stage AMD and 18 eyes of 12 normal subjects were ...
Xu X, Liu X, Wang X, Clark ME, McGwin G, Owsley C, Curcio CA, Zhang Y.   +7 more
europepmc   +4 more sources

Drusen characteristics of type 2 macular neovascularization in age-related macular degeneration

BMC Ophthalmology, 2020
Background Type 2 macular neovascularization (MNV) is supposed to be a rare condition in age-related macular degeneration (AMD). The main purpose of this study was to assess accompanying factors of type 2 MNV in AMD.
Daniel Ahmed, Martin Stattin, Anna-Maria Haas, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei   +5 more
doaj   +1 more source

Posterior Microphthalmia, Peripheral Pigmentary Retinal Changes, Yellow Lesions, and Cleft Lip: A Case Report and Literature Review

Case Reports in Ophthalmological Medicine, 2019
Purpose. Posterior microphthalmia is a sporadic or inherited developmental ocular anomaly that may occur isolated or in association with multiple ocular and systemic anomalies.
Nasser G. Alsaedi, Khalid Alrubaie
doaj   +1 more source

Risk factors associated with reticular pseudodrusen versus large soft drusen [PDF]

, 2014
PURPOSE: To investigate genetic, environmental, and systemic risk factors in prospectively identified subjects with the age-related macular degeneration (AMD) phenotypes of (1) reticular pseudodrusen without large soft drusen and (2) large soft drusen ...
Boddu, S., Freund, K. B., Lee, M. D., Marmor, M., Marsiglia, M., Smith, R. T.   +5 more
core   +3 more sources

Ten-Year Incidence of Fibrosis and risk factors for its development in Neovascular Age-related Macular Degeneration [PDF]

, 2023
Purpose: To report incidence and risk factors for fibrosis at 10 years in a large cohort of neovascular age-related macular degeneration (nAMD). Design: Retrospective, multicenter, cohort study.
Airaldi, Matteo, Aretti, Andrea, Cheung, Chui Ming Gemmy, Cozzi, Elisa, Giuffrida, Francesco Pozzo, Invernizzi, Alessandro, Milella, Paolo, Nassisi, Marco, Romano, Francesco, Staurenghi, Giovanni, Teo, Kelvin Cy, Viola, Francesco   +11 more
core   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source