Results 41 to 50 of about 81,902 (285)

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad   +9 more
wiley   +1 more source

New opportunities and challenges in surveying underground cavities using photogrammetric methods

open access: yesInternational Journal of Mining Science and Technology, 2021
The exploitation of the underground is currently undergoing a major transformation process. Besides mining, alternative ways of utilization are playing an increasingly important role.
Malte J.M. Gurgel, Axel Preusse
doaj   +1 more source

Unemployment and Goverment's Subsidizing

open access: yesOrganizacija, 2011
Unemployment and Goverment's Subsidizing Unemployment has become more and more pressing matter nowadays. Governments all across the world are implementing policies to increase the employment rates back to the levels before the economic downturn.
Dimovski, Vlado   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

InSAR observations reveal interactions between seismic and aseismic slip during and after the 2016 Mw 6.6 Muji earthquake

open access: yesScientific Reports
Studying the relationship between coseismic slip and aseismic creep helps better understand the seismic and aseismic behavior of crustal faults. We use multi-platform synthetic aperture radar (SAR) and global positioning system data to invert for the ...
Jia Xu   +7 more
doaj   +1 more source

Subsidence investigations at the Galatia Site, Salina County, Illinois [PDF]

open access: yes, 1997
Made available in DSpace on 2013-03-29T20:13:27Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) finalreportofsub11vanr.pdf: 2925865 bytes, checksum: 0e3ee355a139488520c032bc81d87760 (MD5) Previous ...
Van Roosendaal, D.J.
core  

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Effects of mining subsidence observed by time-lapse seismic reflection profiling [PDF]

open access: yes, 1995
Extracting coal from underground mineworkings causes the overlying rocks to subside with associated changes in the stress regime. The aim of the study reported here was to apply the surface seismic reflection method to study the effect of subsidence on ...
Al-Rawahy, Salim Y.S.
core  

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