Results 61 to 70 of about 150,966 (300)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The future of underground spatial planning and the resulting potential risks from the point of view of mining subsidence engineering

International Journal of Mining Science and Technology, 2020
The topic of ground movements in Germany has been studied extensively in the past, especially in the field of active mines. The active hard coal mines in Germany were finally shut down in 2018 and lignite mining is expected to take place only until 2038.
Carolina Brücker, Axel Preuße
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

InSAR observations reveal interactions between seismic and aseismic slip during and after the 2016 Mw 6.6 Muji earthquake

Scientific Reports
Studying the relationship between coseismic slip and aseismic creep helps better understand the seismic and aseismic behavior of crustal faults. We use multi-platform synthetic aperture radar (SAR) and global positioning system data to invert for the ...
Jia Xu, Zhiyu Gao, Jie Liu, Wei Yan, Haipeng Guo, Rui Liu, Changrong Yi, Dongxin Xu   +7 more
doaj   +1 more source

Sedimentation and subsidence history of the Lomonosov Ridge [PDF]

, 2006
During the first scientific ocean drilling expedition to the Arctic Ocean (Arctic Coring Expedition [ACEX]; Integrated Ocean Drilling Program Expedition 302), four sites were drilled and cored atop the central part of the Lomonosov Ridge in the Arctic ...
Backman, J., Brinkhuis, H., Clemens, S., Cronin, T., Dickens, G.R., Eynaud, F., Gattacceca, J., Jakobsson, M., Jordan, R.W., Kaminski, M., King, J., Koç, N., Martinez, N.C., Matthiessen, J., McInroy, D., Moore Jr., T.C., Moore, T.C., Moran, K., O'Regan, M., Onodera, J., Pälike, H., Rea, B., Rio, D., Sakamoto, T., Smith, D.C., St. John, K.E.K., Stein, R., Suto, I., Suzuki, N., Takahashi, K., Watanabe, M., Yamamoto, M.   +31 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Persistent elastic behavior above a megathrust rupture patch: Nias island, West Sumatra [PDF]

, 2008
We quantify fore-arc deformation using fossil reefs to test the assumption commonly made in seismic cycle models that anelastic deformation of the fore arc is negligible.
Adams, Agnew, Atwater, Bambang Suwargadi, Barber, Berryman, Bird, Briggs, Chappell, Cheng, Chlieh, Clark, Clarke, Curray, Danny Natawidjaja, DeMets, Dewey, Diament, Dickinson, Djamal, Dudi Prayudi, Edwards, Edwards, Edwards, Egbert, Fairbanks, Farr, Fitch, Geyh, Hamilton, Horton, Hsu, Imam Suprihanto, John Galetzka, Karig, Kelsey, Kelsey, Kelsey, Kerry Sieh, Konca, Kopp, Kopp, Kopp, Ladage, Matsuda, McNeill, Melnick, Meltzner, Milsom, Mitrovica, Moore, Moore, Moore, Natawidjaja, Nelson, Newcomb, Nugraha Sastra, Ota, Peltier, Plafker, Plafker, Plafker, Plafker, Plafker, Prawirodirdjo, Richard W. Briggs, Samuel, Samuel, Satake, Savage, Savage, Schlüter, Scholz, Scoffin, Scoffin, Scoffin, Shimazaki, Sibuet, Sieh, Sieh, Sieh, Sladen, Smith, Smithers, Stein, Stuiver, Stuiver, Stuiver, Taylor, Taylor, Taylor, Taylor, Thatcher, Thomas G. Farr, Tjia, Verstappen, Vita-Finzi, Vita-Finzi, Wang, Whittaker, William H. Amidon, Yamano, Zachariasen, Zachariasen   +103 more
core   +1 more source

Should We Subsidize Longevity? [PDF]

SSRN Electronic Journal, 2009
This paper studies the design of the optimal non linear taxation in an economy where longevity varies across agents, and depends on three factors: longevity genes, health investment and farsightedness. Provided earnings, farsightedness and genes are correlated, governmental intervention can be justified on two grounds: correction for a lack of ...
Leroux, Marie-Louise, Pestieau, Pierre, Ponthière, Grégory   +2 more
openaire   +5 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source