Results 51 to 60 of about 81,902 (285)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Land Subsidence and Earth Fissures in Arizona: Research and Informational Needs for Effective Management.

, 2007
Land subsidence and earth fissures have been part of the landscape of southern and south central Arizona for at least the past seventy years. With urban growth now expanding into former agricultural and undeveloped desert lands, the geologic hazards ...
Arizona Land Subsidence Group
core   +2 more sources

Hydrologic control on natural land subsidence in the shallow coastal aquifer of the Ravenna coast, Italy [PDF]

, 2020
Multiple processes contributing to natural land subsidence in a shallow coastal aquifer near Ravenna (Italy) were identified by analysing the relationships among different data set time series (water table level, rainfall, land reclamation drainage, sea ...
Greggio, Nicolas, Giambastiani, Beatrice Maria Sole, Calabrese, Lorenzo, Luciani, Paolo, Perini, Luisa, Antonellini, Marco, Severi, Paolo, Bonzi, Luciana   +7 more
core   +1 more source

Ethical Foreground and Background in Adult Educator Work

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

Evolution of the Yorkshire, sole pit and east midland basin system, U.K [PDF]

, 1990
The objective of this study is to examine the thermo-mechanical evolution of the Yorkshire(Cleveland), Sole Pit and East Midland Basins, Southern North Sea using theoretical models of basin formation(subsidence) and basin destruction(inversion ...
Dixon, Anthony David George
core  

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

The future of underground spatial planning and the resulting potential risks from the point of view of mining subsidence engineering

International Journal of Mining Science and Technology, 2020
The topic of ground movements in Germany has been studied extensively in the past, especially in the field of active mines. The active hard coal mines in Germany were finally shut down in 2018 and lignite mining is expected to take place only until 2038.
Carolina Brücker, Axel Preuße
doaj   +1 more source

Land subsidence and earth fissures in Arizona : research and informational needs for effective risk management [PDF]

, 2007
: This white paper has been created by Arizona Land Subsidence Group to help educate stakeholders and decision makers by describing the geological features and processes of land subsidence and earth fissures, and the hazards they create.

core  

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source