Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Bullying involvement and substance use among Brazilian adolescent students
Revista Panamericana de Salud Pública, 2018 Objective. Although bullying involvement has been associated with adolescent substance use, most of this evidence comes from high-income countries. Little is known about substance use among perpetrator-victims in low- and middle-income countries.
Natalia Woolley, James Macinko
doaj +1 more source
Parental Substance Abuse As an Early Traumatic Event. Preliminary Findings on Neuropsychological and Personality Functioning in Young Drug Addicts Exposed to Drugs Early. [PDF]
, 2016 open5noParental substance use is a major risk factor for child development, heightening the risk of drug problems in adolescence and young adulthood, and exposing offspring to several types of traumatic events.
Afifi +187 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]
, 2017 Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone +4 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Correction to: Gambling Disorder in Male Violent Offenders in the Prison System: Psychiatric and Substance‑Related Comorbidity [PDF]
, 2022 Carolina Widinghoff +5 more
openalex +1 more source
Attention to the people with substance-related disorders at spanish prisons [PDF]
, 2017 Trabajo fin de grado en EnfermeríaIntroducción: El consumo de drogas genera alteraciones a nivel biopsicosocial y puede dar lugar al ingreso en penitenciarías.
Alonso Valero, Irene +1 more
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
La investigación biomédica sobre abuso de sustancias a través de la base de datos Medline (2006-2010) [PDF]
, 2015 El Abuso de sustancias es uno de los principales problemas sociales y de salud pública a escala mundial. Este estudio analiza la investigación científica sobre los trastornos relacionados con sustancias generado a lo largo del período 2006-2010 así como ...
Agulló Calatayud, Víctor +3 more
core