Results 81 to 90 of about 12,333,606 (294)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Occupational therapy interventions for substance-related disorders in the public primary health care sector in the city of Johannesburg

South African Journal of Occupational Therapy
Introduction: The specific nature of occupational therapy interventions for substance-related disorders in South African primary health care settings remain unclear, despite these disorders posing significant intersecting health and social challenges ...
Kirsty Ferrett, Phakeme Zinhle Mkhize, December Mandlenkosi Mpanza   +2 more
doaj   +1 more source

Caffeine consumption of medical students in Korea: amount and symptoms based on a 2023 survey [PDF]

Korean Journal of Medical Education
Purpose To investigate the form and level of daily caffeine intake recommended above 400 mg in medical students expected to consume caffeinated beverages to enhance their performance.
Seong Woo Choi, Ye Won Kim, Chang Yong Lee, Hyung Su Jang, Hee Seung Chae, Ju Ha Choi, Young Hwii Ko   +6 more
doaj   +1 more source

Substance use-related factors and psychosocial characteristics among Turkish adults with early- and late-onset substance use disorder

The onset of substance use is a strong predictor of substance use disorders and related problems. This study examined the differences between early- and late-onset substance use in personality and substance use characteristics, traumatic experiences, and
Mortan Sevi, Oya, Yüksel, Begüm Ceren, BC, Yüksel, Yüksel BC, Mortan, Sevi O., Mortan Sevi O.   +5 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Prevalence and risk factors for drug use and dependence in university students from Medellín, Colombia, 2009

Revista Facultad Nacional de Salud Pública, 2012
Objective: to determine the prevalence and risk factors for druguse and dependence among students at a university in Medellín,Colombia. Methodology: an analytical study in which 1264students were surveyed using a random sampling, stratified bythe number ...
Andrés F. Tirado O, Matilde Álvarez G, Juan D. Velásquez T, Lina Gómez G, Clara Ramírez P, Alberto R. Vargas G   +5 more
doaj  

Features of Addiction in Binge-Eating Disorder: Considerations for Screening and Treatment

Substance Abuse and Rehabilitation, 2023
Alexandra Paul,1,2 Aleena Ghanta,1,2 Ariana M Chao1– 3 1Department of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing, Philadelphia, PA, USA; 2Department of Psychiatry, Perelman School of Medicine at the University of ...
Paul A, Ghanta A, Chao AM
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Decreasing brain activity caused by acute administration of ketamine and alcohol – A randomized, controlled, observer-blinded experimental study

Frontiers in Pharmacology
IntroductionSubstance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters ...
Luan Oliveira Ferreira, Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A. Paz, Maria K. Otake Hamoy, Gabriela B. Barbosa, Murilo F. Santos, Raína M. Conceição, Anthony Lucas G. Amaral, Karina Dias Resende, Dielly Catrina Favacho Lopes, Moisés Hamoy   +11 more
doaj   +1 more source