Results 81 to 90 of about 678,968 (300)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Caffeine consumption of medical students in Korea: amount and symptoms based on a 2023 survey [PDF]

open access: yesKorean Journal of Medical Education
Purpose To investigate the form and level of daily caffeine intake recommended above 400 mg in medical students expected to consume caffeinated beverages to enhance their performance.
Seong Woo Choi   +6 more
doaj   +1 more source

Attention to the people with substance-related disorders at spanish prisons [PDF]

open access: yes, 2017
Trabajo fin de grado en EnfermeríaIntroducción: El consumo de drogas genera alteraciones a nivel biopsicosocial y puede dar lugar al ingreso en penitenciarías.
Alonso Valero, Irene   +1 more
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Prevalence and risk factors for drug use and dependence in university students from Medellín, Colombia, 2009

open access: yesRevista Facultad Nacional de Salud Pública, 2012
Objective: to determine the prevalence and risk factors for druguse and dependence among students at a university in Medellín,Colombia. Methodology: an analytical study in which 1264students were surveyed using a random sampling, stratified bythe number ...
Andrés F. Tirado O   +5 more
doaj  

Substance use and depression. Comparative course in adolescents [PDF]

open access: yes, 2018
Objective: To examine the relation between depression and substance use in adolescents and the concomitant courses of both disorders. Methods: Four individual interviews were administered to 85 adolescent substance users aged 14-19 years (mean 17.1 years,
Bernard, Mathieu   +6 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

ASSISTANCE TO ADOLESCENTS WHO USE PSYCHOACTIVE SUBSTANCES: ROLE OF THE PSYCHOSOCIAL CARE CENTER

open access: yesCogitare Enfermagem, 2017
The present study aimed to gain insight into the role of a Psychosocial Care Center for Users of Alcohol and other Drugs (CAPS AD) that assists adolescents who usepsychoactive substances, from the views of the professionals of Guardianship Councils and ...
Bruna Rios Paim   +6 more
doaj   +1 more source

Algebraic and Topological Indices of Molecular Pathway Networks in Human Cancers [PDF]

open access: yes, 2014
Protein-protein interaction networks associated with diseases have gained prominence as an area of research. We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia
Hinow, Peter   +2 more
core  

Measuring mental health in criminology research: Lessons from the Drug Use Monitoring in Australia program [PDF]

open access: yes, 2013
Poor mental health among people in the Australian criminal justice system is increasingly being identified and targeted for remediation. This is evidenced by Australian and international governments establishing specialist services for prisoners with ...
Lubica Forsythe
core   +1 more source

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