Results 81 to 90 of about 10,535,264 (292)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Decreasing brain activity caused by acute administration of ketamine and alcohol – A randomized, controlled, observer-blinded experimental study

Frontiers in Pharmacology
IntroductionSubstance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters ...
Luan Oliveira Ferreira, Luan Oliveira Ferreira, Esther Padilha da Silveira, Clarissa A. Paz, Maria K. Otake Hamoy, Gabriela B. Barbosa, Murilo F. Santos, Raína M. Conceição, Anthony Lucas G. Amaral, Karina Dias Resende, Dielly Catrina Favacho Lopes, Moisés Hamoy   +11 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Alternative and complementary therapies in the treatment of eating disorders, addictions and substance use disorders

, 2014
Research over the past decade into eating disorders and substance use disorders has been considerable. Despite this, response to treatment for many remains poor.
Sloane Madden, Smith, Caroline (R11597), Caroline Smith, Madden, Sloane, Fogarty, Sarah (R16673), Sarah Fogarty   +5 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Results of a sector-wide quality improvement initiative for substance-abuse care: an uncontrolled before-after study in Catalonia, Spain. [PDF]

, 2010
BACKGROUND: The Health Department of the Regional Government of Catalonia, Spain, issued a quality plan for substance abuse centers. The objective of this paper is to evaluate the impact of a multidimensional quality improvement initiative in the field ...
Lopez, Rosa M, Suñol Rosa, Rosa M Lopez, Colom Farran, Joan, Lopez Galera, Rosa Maria, Colom Joan, Hilarion, Pilar, Lopez Rosa M, Pilar Hilarion, Rosa Suñol, Lopez, Rosa M., Suñol, Rosa, Hilarion Pilar, Colom, Joan, Groene Oliver, Joan Colom, Oliver Groene, Groene, Oliver, Suñol Sala, Rosa   +18 more
core   +1 more source

A narrative review of trends and challenges of substance use in Punjab: a 10-year analysis of data from 2015 to 2024

Discover Public Health
Background Punjab, a northwestern state of India, is experiencing a serious substance use crisis with wide-ranging public health, social, and economic consequences.
Heena Sachdeva, Manish Sharma, Maninder
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Fiscal Year 2012

, 2012
Annual financial report of the Texas Council on Alzheimer's Disease and Related Disorders documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas Council on Alzheimer's Disease & Related Disorders
core  

A pilot study to assess the feasibility and impact of a brief motivational intervention on problem drug and alcohol use in adult mental health inpatient units : study protocol for a randomized controlled trial [PDF]

, 2014
Background: Substance misuse in those with severe mental health problems is common and associated with poor engagement in treatment and treatment outcomes.
Hermine L Graham, Copello, Alex, Clarke, Latoya, Nick Freemantle, Kathryn Walsh, Birchwood, Max, Copello, Alexandre; id_orcid, Latoya Clarke, Emma Griffith, Walsh, Kathryn, Stefanidou, Chrysi A., Griffith, Emma, Paul McCrone, Graham, Hermine L., Freemantle, Nick, Arsal Rana, Alex Copello, Max Birchwood, Birchwood, M. J., Graham, Hermine, Birchwood, Maximillian, Rana, Arsal, Stefanidou, Chrysi A, McCrone, Paul, Chrysi A Stefanidou   +24 more
core   +2 more sources