Results 61 to 70 of about 678,968 (300)

Vocational Rehabilitation for Individuals With Substance-Related Disorders

Iranian Rehabilitation Journal, 2019
Objectives: The present review study aimed at investigating the vocational rehabilitation of individuals with drug dependence disorders.  Methods: Based on the research method, a comprehensive search was conducted in the following databases: PubMed ...
Younes Doostian, Bahman Bahmani, Ali Farhoudian, Manoochehr Azkhosh, Mohammad Saeed Khanjani   +4 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Patterns of management of patients with dual disorder (psychosis) in Italy: a survey of psychiatrists and other physicians focusing on clinical practice [PDF]

, 2018
© 2018 Clerici, de Bartolomeis, De Filippis, Ducci, Maremmani, Martinotti and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Patients with severe psychotic disorders such as ...
Acquas, Akiskal, Archie, Bacopoulos, Blum, Blum, Bowirrat, Carra, Connelly, Cuomo, De Bartolomeis, De Bartolomeis, Degenhardt, Delisi, Fantini, Fiorillo, Getzen, Gouzoulis-Mayfrank, Grob, Hertzog, Howes, Iasevoli, Kerner, Lambert, Maremmani, Martin, Martinotti, Nesvag, Ostuzzi, Papageorgiou, Regier, Roncero, Rovai, Rubino, Samaha, Samalin, Sugawara, Szkultecka-Debek, Ventriglio, Volkow   +39 more
core   +4 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

O primeiro contato com as drogas: análise do prontuário de mulheres atendidas em um serviço especializado

Saúde em Debate
O estudo objetivou caracterizar e compreender o contexto em que se dá o primeiro contato de mulheres com problemas relacionados ao uso de substâncias psicoativas que procuraram atendimento em um serviço especializado em álcool e outras drogas.
Divane de Vargas, Janaina Soares, Erika Leon, Caroline Figueira Pereira, Talita Dutra Ponce   +4 more
doaj   +1 more source

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults. [PDF]

, 2013
Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence.
Almasy, Laura, Bauer, Lance, Bierut, Laura, Bucholz, Kathleen, Chorlian, David B, Dick, Danielle, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Hesselbrock, Victor, Kang, Sun J, Kramer, John, Kuperman, Sam, Manz, Niklas, Nurnberger, John, Porjesz, Bernice, Rangaswamy, Madhavi, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong   +20 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents [PDF]

, 2007
BACKGROUND: Functional disturbances in reward-related brain systems are thought to play a role in the development of mood, impulse, and substance abuse disorders. Studies in non-human primates have identified brain regions, including the dorsal / ventral
May, John Christopher
core  

Association of Mental Disorders in Early Adulthood and Later Psychiatric Hospital Admissions and Mortality in a Cohort Study of More Than 1 Million Men [PDF]

, 2012
Context  Mental disorders have been associated with increased mortality, but the evidence is primarily based on hospital admissions for psychoses. The underlying mechanisms are unclear.
Batty, G David, Gale, Catharine R., Osborn, David P J, Rasmussen, Finn, Tynelius, Per, Whitley, Elise   +5 more
core   +1 more source