Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Profiles of quality of outpatient care use, associated sociodemographic and clinical characteristics, and adverse outcomes among patients with substance-related disorders. [PDF]
Subst Abuse Treat Prev Policy, 2023 Fleury MJ, Cao Z, Grenier G, Huỳnh C.
europepmc +1 more source
ASSISTANCE TO ADOLESCENTS WHO USE PSYCHOACTIVE SUBSTANCES: ROLE OF THE PSYCHOSOCIAL CARE CENTER
Cogitare Enfermagem, 2017 The present study aimed to gain insight into the role of a Psychosocial Care Center for Users of Alcohol and other Drugs (CAPS AD) that assists adolescents who usepsychoactive substances, from the views of the professionals of Guardianship Councils and ...
Bruna Rios Paim +6 more
doaj +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Predictors of Frequent Emergency Department Use and Hospitalization among Patients with Substance-Related Disorders Recruited in Addiction Treatment Centers. [PDF]
Int J Environ Res Public Health, 2022 Fleury MJ, Cao Z, Grenier G, Huỳnh C.
europepmc +1 more source
Potential therapeutic strategy to treat substance abuse related disorders
, 2020 The “Potential therapeutic strategy to treat substance-abuse-related disorders” session was chaired by Dr. Sulie L. Chang, director of NeuroImmune Phamacology at Seton Hall University.
Chang, S.L.
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Predictors of Death From Physical Illness or Accidental/Intentional Causes Among Patients With Substance-Related Disorders. [PDF]
Can J Psychiatry, 2023 Fleury MJ, Cao Z, Grenier G, Huỳnh C.
europepmc +1 more source
, 2014 Annual financial report of the Texas Council on Alzheimer's Disease and Related Disorders documenting income, expenditures, and other relevant financial information for fiscal year ...
Texas Council on Alzheimer's Disease & Related Disorders
core
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source