Results 141 to 150 of about 1,257,231 (376)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Revista Facultad Nacional de Salud Pública, 2012 Objective: to determine the prevalence and risk factors for druguse and dependence among students at a university in Medellín,Colombia. Methodology: an analytical study in which 1264students were surveyed using a random sampling, stratified bythe number ...
Andrés F. Tirado O +5 more
doaj
Psychiatric disorders among young male adult prisoners: a cross sectional study in a Malaysian prison [PDF]
, 2010 Introduction: In recent years there has been an increase in the number of young people in prison. This study is the firstto look at the proportion of psychiatric disorders among young adultprisoners.
Baharuddin, Azlin +4 more
core
CE 560 Syllabus: Addiction Counseling: Assessments and Treatment of Addiction & Co-Occuring Disorders [PDF]
, 2023 This course addresses the principles of screening, assessment, diagnosis of substance use, induced, and co-occurring disorders in adults and adolescents, and treatment planning.
Moore, Mitch
core +1 more source
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Terrorism, Civil War, One-Sided Violence and Global Burden of Disease [PDF]
, 2013 The purpose of this dissertation was to examine relationships between terrorism, civil war and one-sided violence from 1994-2000 and morbidity and mortality in 2002, as measured by disability-adjusted life years (DALYs), attributable to: (1) major ...
Kerridge, Bradley Townsend
core
Prevalence and correlates of substance use among persons with mental disorders in a Nigerian Psychiatric Hospital [PDF]
, 2013 Few studies in Nigeria have investigated the relationship between psychiatric disorders and substance use. Yet, evidence worldwide suggests that substance related problems might be a major burden among persons with psychiatric disorders.
Abayomi, O +4 more
core +2 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
THE ALCOHOL CONSUMPTION IS AMENDED AFTER BARIATRIC SURGERY? AN INTEGRATIVE REVIEW
ABCD: Arquivos Brasileiros de Cirurgia Digestiva, 2016 Background Bariatric surgery has been an alternative when conservative methods of weight loss fail. Patients undergoing bariatric surgery have an increased risk of up to 6.5% of problems related to alcohol Objective: Integrative review out to analyze ...
Valeria Duarte GREGORIO +5 more
doaj +2 more sources
Frontiers in PharmacologyIntroductionSubstance abuse is a major public health problem. In recent years, ketamine, which is a parenteral anesthetic, has been consumed increasingly as an illicit drug together with alcohol, although little is known of how this association alters ...
Luan Oliveira Ferreira +11 more
doaj +1 more source