Results 51 to 60 of about 601,648 (321)

Neural mechanisms of affective instability and cognitive control in substance use

, 2019
Objective: We explored the impact of affect on cognitive control as this relates to individual differences in affective instability and substance use.
Bodkyn, Carmen N., Holroyd, Clay
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Lifting the Burden of Addiction: Philanthropic Opportunities to Address Substance Use Disorders in the United States [PDF]

, 2015
Substance use disorders (SUDs), also known as substance abuse or addiction, affect an estimated 20 million or more adolescents and adults in the U.S. This guidance provides philanthropic funders with the tools & information to reduce immediate harm from ...
Cecily Wallman-Stokes, Götz Bechtolsheimer, Jacob Appel, Jennifer Gable, Jessica Chiu, Katherina Rosqueta, Rebecca Hobble   +6 more
core  

Substance use among outdoor treatment-seeking patients with mental illness: A case–control study from a tertiary care hospital of northern India

Journal of Education and Health Promotion, 2018
Background: Substance abuse and mental disorder often coexist and may cause several consequences in sociooccupational functioning and health care and management. Indian data are sparse in this area.
Mona Srivastava, Shobhit Jain, Ashok Patel   +2 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The classification of substance and behavioural addictions: A preliminary investigation [PDF]

, 2012
The term addiction has been used to refer to impaired control over substance use for several centuries however recently there has been a shift toward using this term in the context of non-substance use disorders, such as pathological gambling.
McLaughlan, Andre David, Starkey, Nicola J.   +1 more
core   +1 more source

Substance use and psychological disorders among art and non-art university students: an empirical self-report survey [PDF]

, 2018
Media stories often suggest that those working in the creative arts appear to use and abuse psychoactive substances. The aim of the present study was to analyze the relationship between the use of psychoactive substances and the presence of psychological
A Ehrenzweig, A Gyepesi, A Preti, A Roy, B Neighbors, CG Jung, CG Jung, D Knafo, D Newbury-Birch, E Kris, E Kuntsche, ER Peters, F Iszáj, Fruzsina Iszáj, GH Tolson, GJ Feist, Gyöngyi Kökönyei, H Gardner, H Kohut, HJ Eysenck, J Gerevich, J Macleod, J Murray, Judit Farkas, L Degenhardt, L Derogatis, M Dobkin de Rios, M Lynskey, Mark D. Griffiths, Máté Kapitány-Fövény, NC Andreasen, ND Jeste, OF Kernberg, R Urbán, R Urbán, R Verheul, Róbert Urbán, S Freud, S Legleye, TF Babor, TJ Trull, Z Rihmer, Zsolt Demetrovics   +42 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders [PDF]

, 2016
Introduction: Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations.
Agrawal, Arpana, Bucholz, Kathleen K, Conroy, Elizabeth, Degenhardt, Louisa, Heath, Andrew C, Henders, Anjali K, Kristjansson, Sean, Lynskey, Michael T, Madden, Pamela A.F., Martin, Nicholas G, McCutcheon, Vivia V, Nelson, Elliot C, Statham, Dixie J, Todorov, Alexandre A   +13 more
core   +3 more sources

Contractures and Drug Abuse [PDF]

Indian Journal of Physical Medicine & Rehabilitation, 2009
Contracture is limitation of complete range of motion,active or passive, due to joint, muscle or soft-tissuelimitations. Myogenic contractures can be due to trauma,inflammation, degenerative changes, ischemia, andspasticity.
Srikumar V, Wadhwa S, Singh U, Yadav SL, Handa G   +4 more
doaj