Results 151 to 160 of about 2,731,006 (308)

Systematic Review and Meta-Analysis of the Prevalence of Substance Use Among Adolescents in South Africa. [PDF]

Drug Alcohol Rev
Brooke-Sumner C, Marchionatti LE, Mneimneh Z, Harker N, Egbe CO, Jenkins D, Mpisane N, Mosalisa M, Chideya Y, Holland N, Erasmus-Claassen LA, Salum G, Bantjes J.   +12 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

When trauma triggers craving: meta-analytic evidence for the mediating role of negative affect among trauma-exposed individuals who use substances. [PDF]

Eur J Psychotraumatol
DeGrace S, Smith MM, Ethier-Gagnon MA, Cosman T, Sherry SB, Romero-Sanchiz P, Bird B, Tibbo PG, Yakovenko I, Stewart SH.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Hepatocytoprotective Substances

Gastroenterology, 1981
openaire   +2 more sources

Correction: Promoting Sustained Real-Life Benefits of Virtual Reality-Based Interventions in People With Mental Health and Substance Use Disorders: Qualitative Study. [PDF]

JMIR Form Res
Aasen J, Nilsson F, Sørensen T, Leonhardt M.   +3 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Intolerance of uncertainty, psychopathology, and emerging adult sibling relationships. [PDF]

Curr Psychol
Morgan DD, Martin MJ, Ingram PB, Oh W, Rogers CR.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Familial risk factors required to predict earlier adolescent substance use in youth with externalizing disorders. [PDF]

Psychol Addict Behav
Smoker MP, Mattey-Mora PP, Crum KI, Abu-Sultanah M, Murray OK, Chimelis-Santiago JR, Finn PR, Aalsma MC, Hulvershorn LA.   +8 more
europepmc   +1 more source