Results 141 to 150 of about 2,593,245 (346)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Актуальні питання суспільних наук та історії медицини, 2014 Skrytska Natalya. The Formation of the Subject Field of Metaphysical Categories in Terms of Philosophical Ideas of Late Scholastics. The article considers the nature of such metaphysical concepts as essence, being, God, substance, logical quantifier ...
Скрицька Наталія
doaj
Connecticut substance abuse prevention and treatment block grant
, 2011 Biennial; At head of title: Connecticut.; "Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Substance Abuse Prevention."; Latest issue consulted: Uniform application FY 2011; title from cover ...
Connecticut. Dept. of Mental Health and Addiction Services.
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Health Research in AfricaRESUME Introduction. Au Mali, les traumatismes balistiques responsables de pertes de substances mandibulaires, sont souvent causés par une tentative d'autolyse, une agression ou un accident. Le but de notre travail est d’étudier les aspects cliniques et
Théra Thioukany David +8 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Addiction Phenomenology In Substance Use And Non-Substance Use Disorders [PDF]
, 2008 There is growing research evidence and public concern over the burgeoning of disorders which share common features with substance addictions. In order to investigate the presence and role of addiction features in disorders outside of substance addictions,
McLachlan, Andre David
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Substance abuse and women: a comprehensive qualitative analysis of the literature [PDF]
, 1999 Plan BIn this comprehensive meta-analytic research study, substance abuse as it pertains to women is discussed in detail. A brief history of substance use and women will be presented plus a brief history of pharmacology research and its relevance to ...
Gignac, Susan
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