Results 121 to 130 of about 51,824 (261)
Exploring the genetic overlap between substance use disorder and educational attainment
Addiction, EarlyView.Abstract Background and aims Substance use disorder (SUD) is a polygenic psychiatric condition characterized by persistent drug use despite negative consequences. Several studies support that higher cognitive performance and educational attainment (EA) are associated with a reduced risk for SUD.
Judit Cabana‐Domínguez +16 more
wiley +1 more source
The association of methadone use with physical function and frailty among persons who inject drugs
Addiction, EarlyView.Abstract Background and Aims Persons who inject drugs (PWID) experience a high burden of early‐onset frailty, primarily due to multifactorial causes such as infections (human immunodeficiency virus [HIV], hepatitis C virus [HCV]), substance use, and polypharmacy.
Grace L. Kulik +10 more
wiley +1 more source
Brief report: Ketamine‐assisted “bridge therapy” for opioid tapering in complex cases
The American Journal on Addictions, EarlyView.Abstract Background Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25‐year‐old woman with OUD, chronic pain, and major depressive disorder underwent an 8‐week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering. Results Methadone
Mariana C. de Oliveira +11 more
wiley +1 more source
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
Characteristics of male and female injecting drug users of the AjUDE-Brasil II Project
Cadernos de Saúde PúblicaThe object of this study is to compare female and male injection drug users (IDUs) in terms of sociodemographic profile and aspects of their initiation to the use of injection drugs.
Ana Maria de Oliveira Cintra +2 more
doaj
Midwives' Physiological Approach at the Third Stage of Labour: A Scoping Review
Birth, EarlyView.Midwives play a crucial role in supporting a physiological third stage of labour by balancing trust in the woman's body with safety measures to prevent postpartum haemorrhage. This scoping review identifies key midwifery practices that promote natural placenta and highlights the importance of undisturbed, woman‐centred care.
Elena Tarlazzi +9 more
wiley +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Executive function and adult homelessness, true impairment or frontal lobology?
Frontiers in Human NeuroscienceHomelessness is associated with multiple risk factors for neurocognitive impairment. Past research with people experiencing homelessness has described “frontal lobe” dysfunction including behavioral disorders and executive cognitive impairments.
Graham Pluck, Graham Pluck
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez +13 more
wiley +1 more source