Results 131 to 140 of about 51,824 (261)

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Syringe exchange programs in Brazil: preliminary assessment of 45 programs

Cadernos de Saúde Pública
The present study aims to evaluate the current operation of Brazilian syringe exchange programs (SEP). After consulting national and regional networks of people working in projects/ programs aiming to reduce drug-related harm, we identified 134 potential
Elize Massard da Fonseca, José Mendes Ribeiro, Neilane Bertoni, Francisco I. Bastos   +3 more
doaj  

HIV pre-exposure prophylaxis programmatic preferences among people who inject drugs: findings from a discrete choice experiment

Addiction Science & Clinical Practice
Background Pre-exposure prophylaxis (PrEP) holds promise for decreasing new HIV infections among people who inject drugs (PWID), yet daily oral PrEP use is low, and PrEP modality and delivery strategy preferences in this population remain understudied ...
William H. Eger, Angela R. Bazzi, Chad J. Valasek, Carlos F. Vera, Alicia Harvey-Vera, Steffanie A. Strathdee, Heather A. Pines   +6 more
doaj   +1 more source

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]

, 2019
Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Newman, Amy H, Sedighim, Sharona   +4 more
core  

Anti‐seizure medications in patients with post‐stroke epilepsy: A survival analysis study

Epilepsia, EarlyView.
Abstract Objective The role of antiseizure medications (ASMs) in patients with post‐stroke epilepsy (PSE) is still debated. Although a few studies have compared the efficacy of different ASMs on mortality in patients with PSE, overall evidence on the impact of ASM use on survival is limited.
Ippazio Cosimo Antonazzo, Carla Fornari, Gabriele Buongarzone, Pietro Ferrara, Giacomo Crotti, Alberto Zucchi, Paolo Angelo Cortesi, Davide Rozza, Lorenzo Giovanni Mantovani, Giampiero Mazzaglia   +9 more
wiley   +1 more source

Access to highly active antiretroviral therapy for injection drug users: adherence, resistance, and death

Cadernos de Saúde Pública
Injection drug users (IDUs) continue to comprise a major risk group for HIV infection throughout the world and represent the focal population for HIV epidemics in Asia and Eastern Europe/Russia.
David Vlahov, David D. Celentano
doaj  

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Tetanus in Injecting Drug Users, United Kingdom

Emerging Infectious Diseases, 2006
Susan J.M. Hahné, Joanne M. White, Natasha S. Crowcroft, Moira M. Brett, Robert C. George, Nick J. Beeching, Kirsty Roy, David Goldberg   +7 more
doaj   +1 more source

Role of acetaldehyde in alcohol addiction : current evidence and future perspectives [PDF]

, 2011
The effects of alcohol have been widely studied during the past century, corroborating the idea that this tiny chemical compound acts throughout most of our neurotransmitter systems since it is capable of inducing addictive behaviour.
Cacace, Silvana, Cannizzaro, Carla, Plescia, Fulvio   +2 more
core  

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

Equine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell, J. Brandly, W. W. Muir III, J. Page, K. Hopster   +4 more
wiley   +1 more source