Results 181 to 190 of about 25,546 (228)

Glucagon‐Like Peptide‐1 Receptor Agonists in Cocaine Use Disorder: Clinical Observations and Underlying Mechanisms

Fundamental &Clinical Pharmacology, Volume 40, Issue 4, July 2026.
ABSTRACT Background Cocaine use disorder (CUD) remains a major public health concern, characterized by high relapse rates and the absence of approved pharmacological treatments. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), widely prescribed for metabolic disorders, modulate mesolimbic reward pathways and have been proposed as potential ...
Céline Eiden, Ghjulia Chautard, Anne Batisse, Aurélie Aquizerate, Amandine Luquiens, Hélène Donnadieu, Jean‐Luc Faillie, Hélène Peyriere   +7 more
wiley   +1 more source

Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis. [PDF]

Psychol Med
Barr PB, Neale ZE, Bigdeli TB, Chatzinakos C, Harvey PD, Peterson RE, Meyers JL.   +6 more
europepmc   +1 more source

Role of Gram‐Negative Bacterial Infections in Acute‐On‐Chronic Liver Failure

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Acute‐on‐chronic liver failure (ACLF) is a systemic disease characterised by an acute clinical deterioration of pre‐existing liver cirrhosis leading to multiple organ failure due to systemic inflammation. It may be triggered by the translocation of bacteria and bacterial compounds across the gut barrier.
Camilla Cadoli, Volker Müller, Christoph Welsch, Heiko Mühl, Jonel Trebicka, Volkhard A. J. Kempf   +5 more
wiley   +1 more source

Neuroactive steroids for the treatment of depression and anxiety: gaps and promises. [PDF]

Eur Arch Psychiatry Clin Neurosci
Rupprecht R, Schüle C, Gudermann T.
europepmc   +1 more source

Renal Perfusion in Healthy Horses: A Feasibility Study With Contrast‐Enhanced Ultrasound

Veterinary Radiology &Ultrasound, Volume 67, Issue 4, July 2026.
ABSTRACT This study assessed the feasibility of contrast‐enhanced ultrasound (CEUS) for evaluating renal perfusion in horses and compared perfusion parameters between age groups. In a prospective study, eight healthy horses were divided into young (3–5 years, n = 4) and old (16–17 years, n = 4) groups.
Diana Villa Verde Salazar, Marília Alves Ferreira, Pedro Henrique Salles Brito, Ricardo Andrés Ramirez Uscategui, Anna Carolina Mazeto Ercolin, Gabriela Castro Lopes Evangelista, Luiz Paulo Nogueira Aires, Luciano Andrade Silva, Marcus Antônio Rossi Feliciano   +8 more
wiley   +1 more source

Transitions from first drug use to illicit opioid and injection drug use in a multisite rural U.S. cohort of people who use drugs. [PDF]

Harm Reduct J
Fredericksen RJ, Sibley A, Lancaster KE, Jenkins W, Mixson LS, Whitney BM, Ouellet L, Friedmann PD, Korthuis T, Delaney JAC, Tsui JI, Crane HM, Zule W, Young AM, Seal DW, Stopka TJ.   +15 more
europepmc   +1 more source

Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich, Hubert Schrezenmeier, David Alexander Christian Messerer   +2 more
wiley   +1 more source

Clavipectoral Fascial Plane Block for a Permanent Pacemaker Insertion in a Claustrophobic Patient With a History of Substance Abuse: A Case Report. [PDF]

Cureus
Sandeep G, Singha SK, Nazir S, Arun TC, Gupta A.   +4 more
europepmc   +1 more source

The impact and cost-effectiveness of scaling up HCV treatment for achieving elimination among people who inject drugs in England: a synopsis including evidence synthesis and economic modelling.

Health Technol Assess
Ward Z, Simmons R, Fraser H, Trickey A, Kesten J, Gibson A, Reid L, Cox S, Gordon F, McPherson S, Ryder S, Vilar FJ, Miners A, Williams J, Emmanouil B, Desai M, Coughlan L, Harris R, R Foster G, Hickman M, Mandal S, Vickerman P.   +21 more
europepmc   +1 more source

Abuse potential assessment of novel central nervous system active and psychedelic substances for controlled substances act scheduling recommendations. [PDF]

J Psychopharmacol
Henningfield JE, Comer SD, Banks ML, Coe MA, Collins GT, Cooper ZD, Fantegrossi WE, Durgin CJ, Heal DJ, Huskinson SL, Lanier RK, Lynch WJ, Meisch RA, Rowlett JK, Strickland JC, Gannon BM.   +15 more
europepmc   +1 more source