Results 191 to 200 of about 51,224 (282)

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Global Mapping and Visualization of Substance Use Disorders and Treatment: Implications for Priority Setting. [PDF]

Adv Biomed Res
Mazhari SR, Najari A, Sobhani Z, Latifi M.   +3 more
europepmc   +1 more source

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, Volume 13, Issue 21, 13 April 2026.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Trail Making Test performance in early abstinence from methamphetamine: human evidence for a drug-associated Parkinsonian-like phenotype. [PDF]

Front Psychiatry
Dumitrescu AM, Vest MF, Fleckenstein AE, Patterson JC, Ledbetter C, Goeders NE, Loftis JM, Thompson E, Lofton K, Murnane KS.   +9 more
europepmc   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Acute Gluteal Compartment Syndrome and Sciatic Nerve Palsy Following Prolonged Immobilization in an Intravenous Drug User: A Case Report. [PDF]

Am J Case Rep
Papageorgiou P, Giannatos V, Antzoulas P, Argyropoulou E, Koukos C, Kokkalis Z.   +5 more
europepmc   +1 more source

Detecting stigmatizing language in clinical notes with large language models for addiction care. [PDF]

Npj Health Syst
Sethi R, Caskey J, Gao Y, Churpek MM, Miller TA, Mayampurath A, Salisbury-Afshar E, Afshar M, Dligach D.   +8 more
europepmc   +1 more source

Neuroplasticity‐Driven Mechanisms and Therapeutic Targets in the Anterior Cingulate Cortex in Neuropathic Pain

Brain and Behavior, Volume 16, Issue 4, April 2026.
The anterior cingulate cortex (ACC), as the center for pain and emotion integration, causes integration disorders due to excessive synaptic strengthening and glial cell inflammation/synaptic pruning dysregulation. However, traditional drugs have insufficient targeting, and closed‐loop DBS improves symptoms by precisely regulating ACC.
Haibing Xiong, Letai Li, Yanlin Li, Yutong Chen, Jiajie Leng, Tingting Chen   +5 more
wiley   +1 more source

The impact and cost-effectiveness of scaling up HCV treatment for achieving elimination among people who inject drugs in England: a synopsis including evidence synthesis and economic modelling.

Health Technol Assess
Ward Z, Simmons R, Fraser H, Trickey A, Kesten J, Gibson A, Reid L, Cox S, Gordon F, McPherson S, Ryder S, Vilar FJ, Miners A, Williams J, Emmanouil B, Desai M, Coughlan L, Harris R, R Foster G, Hickman M, Mandal S, Vickerman P.   +21 more
europepmc   +1 more source

Clavipectoral Fascial Plane Block for a Permanent Pacemaker Insertion in a Claustrophobic Patient With a History of Substance Abuse: A Case Report. [PDF]

Cureus
Sandeep G, Singha SK, Nazir S, Arun TC, Gupta A.   +4 more
europepmc   +1 more source