Results 131 to 140 of about 2,326,575 (402)

A Departmental Policy Addressing Chemical Substance Abuse [PDF]

open access: bronze, 1986
John Lecky   +7 more
openalex   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

open access: yesAdvanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu   +10 more
wiley   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

open access: yesAdvanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen   +10 more
wiley   +1 more source

Relapse Among Patients Referring to Residential Rehabilitation Centers for Drug Use Disorders in Iran and Its Related Factors

open access: yesIranian Rehabilitation Journal, 2018
Objectives: In this study, we aimed to determine the individual characteristics of clients who were referred to residential rehabilitation centers for drug use disorders and to determine their relapse-related factors.
Omid Massah   +4 more
doaj  

Teen Substance Use and Abuse in the Growing Metro of Des Moines, Iowa [PDF]

open access: yes, 2017
uVoice, a youth philanthropy board comprised of twelve students from seven Des Moines-area high schools, spent 2016 identifying unmet needs of central Iowa youth, specifically issues related to substance abuse.Students wrote and released a "White Paper ...

core  

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

open access: yesAdvanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song   +24 more
wiley   +1 more source

Te Aroha o te Hauangiangi : Māori perspectives on healing from substance abuse : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Māori Studies at Te Pūtahi-ā-Toi School of Māori Studies, Massey University, Palmerston North, Aotearoa/New Zealand [PDF]

open access: yes, 2006
This thesis examines and describes Māori cultural components used in the treatment of substance abuse problems in the Taha Māori Programme at Queen Mary Hospital.
Warbrick, Keremete Te Rangimaria
core  

Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia

open access: yesAdvanced Science, EarlyView.
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji   +12 more
wiley   +1 more source

The Effectiveness of Cognitive-Behavioral-Based Stress Management Training on Anxiety in Female MS Patients

open access: yesIranian Rehabilitation Journal, 2015
Objectives: This present study aims to examine the effectiveness of cognitive-behavioral-based stress management training on anxiety in female MS patients. Methods: This study employed a semi-experimental research method with pre-test post-test, control
Shafigh Mehraban   +3 more
doaj  

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