Results 111 to 120 of about 1,013,046 (307)

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

The ventral hippocampus and nucleus accumbens as neural substrates for cocaine contextual memory reconsolidation

Translational Psychiatry
Addictive drugs engage molecular pathways of associative learning and memory. Drug craving triggered by cues that were once associated with drug intoxication contributes to continued drug-seeking behaviors.
Carolina Caban Rivera, Rachael Price, Ricardo Petrilli Fortuna, Chen Li, Chau Do, Justin Shinkle, Marco G. Ghilotti, Xiangdang Shi, Lynn G. Kirby, George M. Smith, Ellen M. Unterwald   +10 more
doaj   +1 more source

Florida Commission on Mental Health & Substance Abuse Final Report

, 2001
The Florida Commission on Mental Health and Substance Abuse was created in 1999 to conduct a systematic review of the state’s mental health and substance abuse system.
Florida Commission on Mental Health & Substance Abuse
core  

The Relationship between Substance Abuse Treatment Completion, Sociodemographics, Substance Use Characteristics, and Criminal History

, 2012
The purpose of this study is to determine if a significant relationship exists between the sociodemographics, substance use characteristics, criminal history, and completion of substance abuse treatment. In this study, 115 individuals being monitored for
Turan, Reyhan, Reyhan Turan, Yargic, Ilhan, Ilhan Yargic   +3 more
core   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study

BMJ Public Health
Background This study investigated the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs) and incident atrial fibrillation (AF) and examined whether psychological distress mediates these associations in the ...
Safak Caglayan, Ole K Grønli, Anne Høye   +2 more
doaj   +1 more source

Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics

Advanced Science, EarlyView.
This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka, Bushra Raahat, Spyros Tragoudas, Hui Li   +3 more
wiley   +1 more source

Identifying Key Intervention Attributes Driving Acceptability of Spouse/Partner-Centered HIV Interventions in Vietnam Using Conjoint Analysis

Patient Preference and Adherence
Thi Huong Dang,1 Thi Thanh Thuy Dinh,1 Lynn T Nguyen,2 Truong Giang Nguyen,1 Le Minh Giang,1,3 Sung-Jae Lee,4 Chunqing Lin41Center for Training and Research on Substance Abuse - HIV, Hanoi Medical University, Hanoi, Vietnam; 2David Geffen School of ...
Dang TH, Dinh TTT, Nguyen LT, Nguyen TG, Giang LM, Lee SJ, Lin C   +6 more
doaj  

The Effectiveness of Cognitive-Behavioral-Based Stress Management Training on Anxiety in Female MS Patients

Iranian Rehabilitation Journal, 2015
Objectives: This present study aims to examine the effectiveness of cognitive-behavioral-based stress management training on anxiety in female MS patients. Methods: This study employed a semi-experimental research method with pre-test post-test, control
Shafigh Mehraban, Bahman Bahmani, Mojtaba Azimian, Poorya Rezasoltani   +3 more
doaj  

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source