Results 111 to 120 of about 843,215 (258)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

The ventral hippocampus and nucleus accumbens as neural substrates for cocaine contextual memory reconsolidation

Translational Psychiatry
Addictive drugs engage molecular pathways of associative learning and memory. Drug craving triggered by cues that were once associated with drug intoxication contributes to continued drug-seeking behaviors.
Carolina Caban Rivera, Rachael Price, Ricardo Petrilli Fortuna, Chen Li, Chau Do, Justin Shinkle, Marco G. Ghilotti, Xiangdang Shi, Lynn G. Kirby, George M. Smith, Ellen M. Unterwald   +10 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study

BMJ Public Health
Background This study investigated the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs) and incident atrial fibrillation (AF) and examined whether psychological distress mediates these associations in the ...
Safak Caglayan, Ole K Grønli, Anne Høye   +2 more
doaj   +1 more source

Teen Substance Use and Abuse in the Growing Metro of Des Moines, Iowa [PDF]

, 2017
uVoice, a youth philanthropy board comprised of twelve students from seven Des Moines-area high schools, spent 2016 identifying unmet needs of central Iowa youth, specifically issues related to substance abuse.Students wrote and released a "White Paper ...

core  

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

The Effectiveness of Cognitive-Behavioral-Based Stress Management Training on Anxiety in Female MS Patients

Iranian Rehabilitation Journal, 2015
Objectives: This present study aims to examine the effectiveness of cognitive-behavioral-based stress management training on anxiety in female MS patients. Methods: This study employed a semi-experimental research method with pre-test post-test, control
Shafigh Mehraban, Bahman Bahmani, Mojtaba Azimian, Poorya Rezasoltani   +3 more
doaj  

Model Policies for Juvenile Justice and Substance Abuse Treatment [PDF]

, 2008
Based on lessons learned from RWJF's Reclaiming Futures initiative, recommends federal, state, and local policy options for combining juvenile justice system reforms with improved substance abuse treatment and community engagement ...

core  

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Barriers and solutions to addressing tobacco dependence in addiction treatment programs. [PDF]

, 2006
Despite the high prevalence of tobacco use among people with substance use disorders, tobacco dependence is often overlooked in addiction treatment programs.
Foulds, Jonathan, Guydish, Joseph, Steinberg, Marc, Williams, Jill, Ziedonis, Douglas M   +4 more
core   +1 more source