Results 111 to 120 of about 293,407 (259)

Correction to: Metacognitive therapy and work-focused interventions for patients on sick leave due to anxiety and depression: study protocol for a randomised controlled wait-list trial

Trials, 2021
Kenneth Sandin, Ragne G. H. Gjengedal, Kåre Osnes, Marit Hannisdal, Torkil Berge, Jonas S. R. Leversen, Lars G. Røv, Silje Endresen Reme, Suzanne Lagerveld, Roland Blonk, Hans M. Nordahl, Gemma Shields, Adrian Wells, Odin Hjemdal   +13 more
doaj   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Perceived social support of learners at risk of substance abuse at two selected high schools within the Cape metropolitan area

, 2022
Magister Curationis - MCurSubstance abuse contributes towards mental illness as part of the global burden of disease. In South Africa, substance abuse presents amongst learners at secondary schools. Substance use affects academic performance negatively
Cassiem, Sabiyah
core  

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Competencies for Canada’s substance abuse workforce.

, 2010
This report forms a supportive resource that identifies the technical and behavioural competencies required to perform effectively in the substance abuse field (from health promotion, support and outreach, counselling, withdrawal management, and ...

core  

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Relationship Between Social, Economic and Cultural Factors and Women’s Tendency Toward Crystal Methamphetamine or Opium Use

Iranian Rehabilitation Journal, 2018
Objectives: High prevalence of stimulants use –especially crystalline methamphetamine (crystal meth)-, which required extensive medical and rehabilitation interventions is a major problem in Iran; health care system.
Omid Massah, Ali Farhoudian, Roya Noori, Salaheddin Ghaderi, Elaheh Ahounbar, Seyed Hadi Mousavi   +5 more
doaj  

Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment

Harm Reduction Journal
Introduction Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD). The
Lars Lien, Ingeborg Bolstad, Jørgen G. Bramness   +2 more
doaj   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source