Results 91 to 100 of about 293,407 (259)

Substance abuse and women: a comprehensive qualitative analysis of the literature

, 1999
Plan BIn this comprehensive meta-analytic research study, substance abuse as it pertains to women is discussed in detail. A brief history of substance use and women will be presented plus a brief history of pharmacology research and its relevance to ...
Gignac, Susan
core  

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Therapeutic Community Effectiveness on Self-Esteem and Relapse Rate among Drug Users

Journal of Rehabilitation, 2012
Objective: In recent years, the Therapeutic Community(TC) has become a widespread treatment alternative for drug addicts. TC have been widely studied with emphasis on thair effectiveness.
Mosayyeb Yarmohammadi-Vasel, Ali Farhoudian, Mohammad Hassan Farhadi, Mahmoud Tavakkoli   +3 more
doaj  

Depression and Substance Abuse: A Rationalization of a Vicious Circle [PDF]

While a mind-altering-substance consumption alleviates current level of depression, it facilitates future depression. Our analysis incorporates this trade off and shows that the stationary state of a consistently overly ambitious sophisticated substance ...
Faria, João Ricardo, Levy, Amnon
core  

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

The ventral hippocampus and nucleus accumbens as neural substrates for cocaine contextual memory reconsolidation

Translational Psychiatry
Addictive drugs engage molecular pathways of associative learning and memory. Drug craving triggered by cues that were once associated with drug intoxication contributes to continued drug-seeking behaviors.
Carolina Caban Rivera, Rachael Price, Ricardo Petrilli Fortuna, Chen Li, Chau Do, Justin Shinkle, Marco G. Ghilotti, Xiangdang Shi, Lynn G. Kirby, George M. Smith, Ellen M. Unterwald   +10 more
doaj   +1 more source

Comparison of substance abuse and its causes among Tehran University of Medical Sciences and Tehran University students [PDF]

Background: Nowadays drug abuse and addiction is one of the most important health, social and political problems in the world. This study has been done for compares substance abuse and its related factors in both Tehran and Tehran University of Medical
رضا خانی مقدم, حامد, شجاعی زاده, داوود, صحبت زاده, رزاق, سوادپور, محمدتقی, لشگرآرا, بهنام, صفری, حسین   +5 more
core  

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Life course adversity and risk of incident atrial fibrillation: causal mediation analysis of psychological distress in the population-based Tromsø Study

BMJ Public Health
Background This study investigated the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs) and incident atrial fibrillation (AF) and examined whether psychological distress mediates these associations in the ...
Safak Caglayan, Ole K Grønli, Anne Høye   +2 more
doaj   +1 more source