Results 131 to 140 of about 843,215 (258)
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss
Advanced Science, EarlyView.. ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao +9 more
wiley +1 more source
The Partnership Attitude Tracking Study [PDF]
, 2006 Presents findings from a survey that examines adolescents' attitudes about illegal drugs and abuse of prescription drugs.
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Advanced Science, EarlyView.A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma +15 more
wiley +1 more source
Comparing teen substance use in northern New Hampshire to rural use nationwide [PDF]
, 2013 Using data administered in 2011 from the Carsey Institute’s Coös Youth Study and the National Survey on Drug Use and Health, this brief compares teen substance use patterns in New Hampshire’s most rural county to patterns among rural youth nationwide ...
Van Gundy, Karen T.
core +1 more source
Advanced Science, EarlyView.A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo +8 more
wiley +1 more source
Incidence of Substance Abuse in the Workplace [PDF]
, 2002 A survey of employers' attitudes regarding the prevalence of drugs in the workplace, how employee drug use impacts their firm, and the effectiveness of company policies to treat and prevent employee substance ...
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Advanced Science, EarlyView.Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu +14 more
wiley +1 more source
Reforming Juvenile Justice Systems: Beyond Treatment [PDF]
, 2010 Evaluates the role of youth development and cultural competence in the Reclaiming Futures initiative to improve substance abuse interventions as part of juvenile justice reform.
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Advanced Science, EarlyView.This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun +9 more
wiley +1 more source