Results 31 to 40 of about 841,730 (362)

Neuroinflammatory history results in overlapping transcriptional signatures with heroin exposure in the nucleus accumbens and alters responsiveness to heroin in male rats

Translational Psychiatry
Recent progress in psychiatric research has highlighted neuroinflammation in the pathophysiology of opioid use disorder (OUD), suggesting that heightened immune responses in the brain may exacerbate opioid-related mechanisms.
Gabriele Floris, Mary Tresa Zanda, Konrad R. Dabrowski, Stephanie E. Daws   +3 more
doaj   +1 more source

Mental health among northern New Hampshire young adults: depression and substance problems higher than nationwide [PDF]

, 2013
This brief uses data on depressive and substance abuse symptoms from two surveys administered in 2011—the Coös Youth Study and the National Survey on Drug Use and Health—to compare mental health patterns among young adults in Coös County, New Hampshire ...
Van Gundy, Karen T.
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Guidelines for Organizing Art Exhibitions on Addiction and Recovery [PDF]

, 2009
Outlines the Innovators Combating Substance Abuse program's model for exhibiting art by those in addiction recovery as a way to offer insight into substance abuse and recovery.

core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Anaesthesia and substance abuse [PDF]

Anaesthesia, 1989
SummaryCurrent practices in the abuse of illicit drugs in the United Kingdom are described with particular reference to their pathological effects and the implications for anaesthesia. Practical guidelines are given for the anaesthetic and peri‐ and postoperative management of addicts.
N. Soni, P. R. Wood
openaire   +3 more sources

The Link Between Intimate Partner Violence, Substance Abuse and Mental Health in California [PDF]

, 2011
Presents findings about how Californians who have been victims of intimate partner violence as adults are more likely to report serious psychological distress, violence-related substance abuse, and need for mental health and/or substance abuse ...
David Grant, Elaine Zahnd, May Jawad Aydin, Sue Holtby   +3 more
core  

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Comparing the effect of buprenorphine and methadone in the reduction of methamphetamine craving: a randomized clinical trial

Trials, 2017
Background We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. Methods Patients were randomized into one of two groups.
Jamshid Ahmadi, Leila Razeghian Jahromi
doaj   +1 more source

Smoking among inpatients in treatment for substance use disorders: prevalence and effect on mental health and quality of life

BMC Psychiatry, 2021
Background Smoking is still prevalent among people with substance use disorders. The objective of this study was to investigate the prevalence of smoking among patients in treatment for substance use disorders and to analyze the effect of smoking both at
Lars Lien, Ingeborg Bolstad, Jørgen G. Bramness   +2 more
doaj   +1 more source