Results 41 to 50 of about 981,064 (308)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Substance Abuse Amongst Refugee Youth: A Scoping Review [PDF]

, 2023
Purpose of Review: Identify and map health, economic, and social consequences of substance abuse, especially because the impacts of substance abuse can adversely and disproportionally affect refugee youth.
Eacersall, Douglas, Khorshed Alam, Alam, Khorshed, Mohsin, Mohd, Douglas Eacersall, Elijah Aleer, Mohd Mohsin, Aleer, Elijah, Afzalur Rashid, Rashid, Afzalur   +9 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Priorities for public health preparedness for psychedelics: education, workforce readiness, and strategic information needs in a rapidly changing landscape

Frontiers in Public Health
Use of psychedelic substances is increasing across unregulated, state-regulated, research, ceremonial/religious, and medical settings in the United States.
R. Cameron Wolf, Rick Lambert, Sara Shoar, Sara Shoar, Joshua S. Hunt, Ingrid Donato, Neeraj Gandotra   +6 more
doaj   +1 more source

Using Goal Achievement Training in juvenile justice settings to improve substance use services for youth on community supervision

Health & Justice, 2018
Background The link between substance use and involvement in the juvenile justice system has been well established. Justice-involved youth tend to have higher rates of drug use than their non-offending peers.
Jacqueline Horan Fisher, Jennifer E. Becan, Philip W. Harris, Alexis Nager, Connie Baird-Thomas, Aaron Hogue, John P. Bartkowski, Tisha Wiley, The JJ-TRIALS Cooperative   +8 more
doaj   +1 more source

Smoking among inpatients in treatment for substance use disorders: prevalence and effect on mental health and quality of life

BMC Psychiatry, 2021
Background Smoking is still prevalent among people with substance use disorders. The objective of this study was to investigate the prevalence of smoking among patients in treatment for substance use disorders and to analyze the effect of smoking both at
Lars Lien, Ingeborg Bolstad, Jørgen G. Bramness   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Other title: Connecticut substance abuse prevention and treatment block grant

, 2017
Biennial; At head of title: Connecticut.; "Substance Abuse and Mental Health Services Administration, Center for Substance Abuse Treatment, Center for Substance Abuse Prevention.
Connecticut. Department of Mental Health and Addiction Services.
core   +1 more source

Initial Feasibility of a Woman-Focused Intervention for Pregnant African-American Women

International Journal of Pediatrics, 2011
African-American women who use crack are vulnerable to HIV because of the complex social circumstances in which they live. Drug-abuse treatment for these women during pregnancy may provide time for changing risk behaviors.
Hendrée E. Jones, Nancy D. Berkman, Tracy L. Kline, Rachel Middlesteadt Ellerson, Felicia A. Browne, Winona Poulton, Wendee M. Wechsberg   +6 more
doaj   +1 more source