Results 61 to 70 of about 2,275,426 (429)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

The Link Between Intimate Partner Violence, Substance Abuse and Mental Health in California [PDF]

open access: yes, 2011
Presents findings about how Californians who have been victims of intimate partner violence as adults are more likely to report serious psychological distress, violence-related substance abuse, and need for mental health and/or substance abuse ...
David Grant   +3 more
core  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Python (deep learning and machine learning) for EEG signal processing on the example of recognizing the disease of alcoholism [PDF]

open access: yes, 2020
Alcoholism is one of the most common diseases in the world. This type of substance abuse leads to mental and physical dependence on ethanol-containing drinks. Alcoholism is accompanied by progressive degradation of the personality and damage to the internal organs. Today still not exists a quick diagnosis method to detect this disease.
arxiv   +1 more source

Racial discrimination, gender discrimination, and substance abuse among Latina/os nationwide.

open access: yesCultural diversity & ethnic minority psychology, 2014
This study investigates the relationship between discrimination and substance abuse among Latina/os, and further examines whether this relationship differs by gender and type of discrimination. Analyses focus on the Latina/o respondents (n = 1,039 men; n
Angie Denisse Otiniano Verissimo   +3 more
semanticscholar   +1 more source

Using Goal Achievement Training in juvenile justice settings to improve substance use services for youth on community supervision

open access: yesHealth & Justice, 2018
Background The link between substance use and involvement in the juvenile justice system has been well established. Justice-involved youth tend to have higher rates of drug use than their non-offending peers.
Jacqueline Horan Fisher   +8 more
doaj   +1 more source

Computational Support for Substance Use Disorder Prevention, Detection, Treatment, and Recovery [PDF]

open access: yesarXiv, 2020
Substance Use Disorders (SUDs) involve the misuse of any or several of a wide array of substances, such as alcohol, opioids, marijuana, and methamphetamine. SUDs are characterized by an inability to decrease use despite severe social, economic, and health-related consequences to the individual.
arxiv  

Attention-Deficit/Hyperactivity Disorder and Substance Abuse

open access: yesPediatrics, 2014
Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders are inextricably intertwined. Children with ADHD are more likely than peers to develop substance use disorders.
Elizabeth B. Harstad, S. Levy
semanticscholar   +1 more source

Homelessness and Substance Abuse: Is Mandatory Treatment the Solution? [PDF]

open access: yes, 1994
For the government to be successful in addressing homelessness, it must focus on the link between homelessness and substance abuse. In New York City and elsewhere, advocates are reluctant to publicize the connection between substance abuse and ...
Abbott, Melanie B.
core   +1 more source

The burden of intracranial atherosclerosis on cerebral small vessel disease: A community cohort study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Exploring the prevalence and association between intracranial atherosclerosis (ICAS) and cerebral small vessel diseases (CSVD), this study delved beyond the current scope, utilising high‐resolution vessel wall MRI (HRVW‐MRI) to investigate how subtle changes in intracranial atherosclerotic features influence the various burdens of ...
Joseph Amihere Ackah   +6 more
wiley   +1 more source

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