Results 41 to 50 of about 48,225 (312)

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Adolescent Substance Abuse Screening [PDF]

open access: yes, 2020
Adolescent substance use is a key public health problem in rural Ohio. Primary care nurses lack substance use screening knowledge and skills. Early screening and detection of possible substance use issues aids in directing patients to appropriate health ...
Lynch, Wesley W.
core   +1 more source

Noticing and helping the neglected child: A Review of the literature [PDF]

open access: yes, 2010
This report presents findings from a systematic literature review examining the evidence on the extent to which practicioners are equpped to recoconise and respond to the indicators that a child's needs are likely to be or are being neglected, whatever ...
Daniel, Brigid   +3 more
core   +1 more source

Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality

open access: yesSultan Qaboos University Medical Journal, 2017
Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine ...
Maryam Akhgari   +3 more
doaj   +1 more source

FORENSIC PSYCHIATRIC ASSESSMENT OF THE CRIMINAL AND CIVIL RESPONSIBILITY OF MENTALLY DISORDERED PERSONS [PDF]

open access: yesThe Egyptian Journal of Forensic Sciences and Applied Toxicology, 2018
Background:The psychiatric assessment of individuals involved in legal proceedings had significantly been advanced during the past decades. Aim of study: To estimate the prevalence of criminal and civil problems among mentally disordered persons ...
Ahmed Hamoda   +4 more
doaj   +1 more source

Detecting Substance Abuse in the Emergency Department: A 10-Year Comparative Study [PDF]

open access: yesISRN Emergency Medicine, 2013
Aims. We have retrospectively analyzed the variations in the clinical profile of patients with a positive consumption of alcohol and/or drugs of abuse that have been confirmed and treated in the Emergency Department of a Virgen de La Arrixaca University Hospital in Murcia (Spain) after a period of 10 years.
Fernando Espi Martinez   +3 more
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Sexual harassment and eating disorders in female elite athletes - A controlled study [PDF]

open access: yes, 2003
The aims were to examine the percentage of female elite athletes and controls reporting sexual harassment and abuse (SHAB), and whether a higher percentage of female athletes with eating disorders (ED) had experienced SHAB.
Sundgot-Borgen, J   +4 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Novel technologies in detection, treatment and prevention of substance use disorders [PDF]

open access: yes, 2018
Substance use disorders are a widely recognized problem, which affects various levels of communities and influenced the world socioeconomically. Its source is deeply embedded in the global population.
Moulahoum, Hichem   +3 more
core   +1 more source

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