Results 41 to 50 of about 3,724,758 (302)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Prevalence Estimates for Pharmacological Neuroenhancement in Austrian University Students: Its Relation to Health-Related Risk Attitude and the Framing Effect of Caffeine Tablets

Frontiers in Pharmacology, 2018
Background: Pharmacological neuroenhancement (PN) is defined as the use of illicit or prescription drugs by healthy individuals for cognitive-enhancing purposes.
Pavel Dietz, Pavel Dietz, Benedikt Iberl, Emanuel Schuett, Mireille van Poppel, Mireille van Poppel, Rolf Ulrich, Matteo Christian Sattler, Matteo Christian Sattler   +8 more
doaj   +1 more source

A Quantitative LC–MS/MS Method for the Detection of 16 Synthetic Cathinones and 10 Metabolites and Its Application to Suspicious Clinical and Forensic Urine Samples

Pharmaceuticals, 2022
Background: Synthetic cathinones currently represent one of the most predominant (sub)-classes of new psychoactive substance (NPS) in illicit drug markets.
Abdulaziz A. Aldubayyan, Erika Castrignanò, Simon Elliott, Vincenzo Abbate   +3 more
doaj   +1 more source

AI impact to Detect Fraud & Substance Abuse

International Journal of Intelligent Systems and Applications in Engineering, 2023
Conventional techniques of inquiry and diagnosis have been transformed by the use of AI in fraud detection and drug usage monitoring. Artificial intelligence-powered systems utilise machine learning, natural language processing, and predictive analytics to identify patterns, anomalies, and hidden hints that could indicate drug addiction or fraud.
openaire   +1 more source

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Journal of Alcoholism & Drug Dependence, 2018
Using hair as a biological specimen to analyze drug abuse has been receiving elevated attention during last years because of flexibility of collection procedure and because hair does not autolysis like other body fluids or tissues. Hair testing provides a broad-spectrum detection window after drug exposure than urine testing. Hair analysis has specific
Ahmed R Ragab, Maha K Al Mazroua, Mona A El Harouny, Moustaf M Afify, Mohamed Omran, Calrole Katbai, Mohamed A Al Qurnay, Ismaiel Al Saeed, Faisyl Al Zweide   +8 more
openaire   +1 more source

Detecting Substance Abuse in the Emergency Department: A 10-Year Comparative Study [PDF]

ISRN Emergency Medicine, 2013
Aims. We have retrospectively analyzed the variations in the clinical profile of patients with a positive consumption of alcohol and/or drugs of abuse that have been confirmed and treated in the Emergency Department of a Virgen de La Arrixaca University Hospital in Murcia (Spain) after a period of 10 years.
Fernando Espi Martinez, Joaquin Nieto Munuera, Jose Antonio Noguera Velasco, Fernando Espi Forcen   +3 more
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A formação do enfermeiro e o fenômeno das drogas no estado do Rio de Janeiro - Brasil: atitudes e crenças La formación del enfermero y el fenómeno de las drogas en el estado de Rio de Janeiro - Brasil: actitudes y creencias Nursing formation and the drugs phenomenon in the state of Rio de Janeiro - Brazil: attitudes and beliefs

Revista Latino-Americana de Enfermagem, 2005
O presente estudo consistiu em identificar as atitudes e crenças em relação ao fenômeno das drogas, de alunos matriculados em cursos de graduação em Enfermagem de Universidade Pública do Rio de Janeiro (Brasil).
Gertrudes Teixeira Lopes, Margarita Antonia Villar Luis   +1 more
doaj   +1 more source

FORENSIC PSYCHIATRIC ASSESSMENT OF THE CRIMINAL AND CIVIL RESPONSIBILITY OF MENTALLY DISORDERED PERSONS [PDF]

The Egyptian Journal of Forensic Sciences and Applied Toxicology, 2018
Background:The psychiatric assessment of individuals involved in legal proceedings had significantly been advanced during the past decades. Aim of study: To estimate the prevalence of criminal and civil problems among mentally disordered persons ...
Ahmed Hamoda, Adel El-Zaid, Ayat Hemeda, Amal Ahmed, Safaa Eldabe   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source