Results 51 to 60 of about 48,225 (312)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Sphincter of oddi dysfunction induced by ketamine: A case report

Clinical Case Reports
Key Clinical Message Chronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection.
Nava Raj Sharma, Arjun Basnet, Saral Lamichhane, Kripa Tiwari, Jeffy Varghese, Sudarshan Gautam, Madalasa Pokhrel   +6 more
doaj   +1 more source

A benchmarking approach for characterizing providers’ patterns of treating patients with substance use disorder

Healthcare Analytics, 2023
It is difficult to identify fraud, waste, and abuse (FWA) in substance use disorder (SUD) treatment. Insurers use outlier detection models to detect SUD-related FWA but these models require credible benchmarks based on cross-payer claims data.
Sivagaminathan Palani, Steven D. Pizer, Cecille Joan Avila, Austin B. Frakt, Kiersten L. Strombotne, Melissa M. Garrido   +5 more
doaj   +1 more source

Validity of Substances of Abuse Detection in Hair by Biochips Array Technology

Journal of Alcoholism & Drug Dependence, 2018
Using hair as a biological specimen to analyze drug abuse has been receiving elevated attention during last years because of flexibility of collection procedure and because hair does not autolysis like other body fluids or tissues. Hair testing provides a broad-spectrum detection window after drug exposure than urine testing. Hair analysis has specific
Ahmed R Ragab, Maha K Al Mazroua, Mona A El Harouny, Moustaf M Afify, Mohamed Omran, Calrole Katbai, Mohamed A Al Qurnay, Ismaiel Al Saeed, Faisyl Al Zweide   +8 more
openaire   +1 more source

Systematic review of interventions for the secondary prevention and treatment of emotional abuse of children by primary carers [PDF]

, 2008
Background Emotional abuse (or psychological maltreatment, as it is more commonly called in the US) is an inadequately researched and poorly understood concept, despite increasing awareness about the harm it can cause to children‟s lives.
Sidebotham, Peter, Paul, Moli, Barlow, Jane, Carter, Yvonne, McMillan, Anita Schrader, Stewart-Brown, Sarah L.   +5 more
core  

AI impact to Detect Fraud & Substance Abuse

International Journal of Intelligent Systems and Applications in Engineering, 2023
Conventional techniques of inquiry and diagnosis have been transformed by the use of AI in fraud detection and drug usage monitoring. Artificial intelligence-powered systems utilise machine learning, natural language processing, and predictive analytics to identify patterns, anomalies, and hidden hints that could indicate drug addiction or fraud.
openaire   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Prevalence and predictors of substance use as a factor in suicide in the USA, 2015–2020: a repeated cross-sectional analysis

BMJ Public Health
Background US rates of substance abuse and suicide mortality increased dramatically in recent years, but little is known about how rising rates of drug and alcohol use are associated with suicide.
Julie A Phillips
doaj   +1 more source

Cut-off points for screening at-risk drinking by AUDIT-C Korean version at emergency department

Turkish Journal of Emergency Medicine, 2018
Purpose: To reduce problems caused by alcohol drinking, it is necessary to identify those with ‘at-risk drinking’ behavior to maximize therapeutic access or intervention.
Kyung Wan Lee, Yoon Hee Choi, Jae Hee Lee   +2 more
doaj   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source