Results 151 to 160 of about 1,461,789 (340)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice

Iranian Journal of Medical Sciences, 2016
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternative substances such as methadone, its use may not lead to the desired result due to the lack of mental tranquility during the withdrawal period.
Majid Motaghinejad, Goudarz Sadeghi-Hashjin, Mohammad Kazem Koohi, Seyed Morteza Karimian   +3 more
doaj  

Perceived discrimination and mental health disorders : the South African Stress and Health study (SASH) [PDF]

, 2009
The original publication is available at http://www.samj.org.zaObjectives. To describe the demographic correlates of perceived discrimination and explore the association between perceived discrimination and psychiatric disorders. Design.
Allen Herman, D R Williams, Dan J Stein, Dan J Stein, Edith Madela-mntla, Hashim Moomal, On Myer, Pamela B Jackson, Pamela B Jackson, Soraya Seedat   +9 more
core   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Impact of social determinants on opioid use disorder treatment engagement after release from jail: a case note content analysis

Addiction Science & Clinical Practice
Background Despite strong evidence that sustained engagement in OUD treatment reduces overdose risk, individuals leaving jail face substantial barriers to initiating and maintaining care.
Justin S. Bell, Jodie M. Dewey, Dennis P. Watson, Carol Johnstone, John S. Palmer, Rachel Kurz, Christine E. Grella   +6 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A comprehensive overview on Kratom [PDF]

, 2016
Kratom (Mitragyna speciosa Korth) is a tropical tree, indigenous to South East Asia. Historically, the plant is locally used as a stimulant, a remedy in traditional medicine and in social context.
Acciavatti, T., Bersani, F. S., Cinosi, E., Corazza, O., Demetrovics, Z., Di Giannantonio, M., Farkas, J., Kapitány-Fövény, M., Li, J. H., Lupi, M., Marini, S., Martinotti, G., Piazzon, G., Roman-Urrestarazu, A., Santacroce, R., Simonato, P., Singh, D., Vicknasingam, B., Yu, W. J.   +18 more
core  

Substance-Related Disorder [PDF]

, 2020
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Healing a Broken System: Veterans and the War on Drugs [PDF]

, 2012
This report examines the plight of returning veterans who struggle with incarceration and psychological wounds of war such as addiction and post-traumatic stress disorder -- and suggests reforms that could improve the health and preserve the freedom of ...

core