Results 141 to 150 of about 53,729,253 (423)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Subdiffusive model of substance releasing from a thick membrane [PDF]
arXiv, 2008 We study both theoretically and experimentally the process of subdiffusive substance releasing from a thick membrane. The theoretical model uses the subdiffusion equation with fractional time derivative and specific boundary conditions at the membrane surfaces. Using a special \textit{ansatz} we find analytical formulas describing the time evolution of
arxiv
Computational Support for Substance Use Disorder Prevention, Detection, Treatment, and Recovery [PDF]
arXiv, 2020 Substance Use Disorders (SUDs) involve the misuse of any or several of a wide array of substances, such as alcohol, opioids, marijuana, and methamphetamine. SUDs are characterized by an inability to decrease use despite severe social, economic, and health-related consequences to the individual.
arxiv
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Harm Reduction JournalBackground In response to the overdose crisis, a collaborative group of two community-based organizations, a health authority and a research institute in Vancouver, Canada, implemented a pilot community-based drug checking (CBDC) intervention for sexual ...
Pierre-julien Coulaud +6 more
doaj +1 more source
Leveraging Large Language Models to Analyze Emotional and Contextual Drivers of Teen Substance Use in Online Discussions [PDF]
arXivAdolescence is a critical stage often linked to risky behaviors, including substance use, with significant developmental and public health implications. Social media provides a lens into adolescent self-expression, but interpreting emotional and contextual signals remains complex.
arxiv
Modeling the Intercelular Exchange of Signalling Molecules depending on Intra- and Inter-Cellular Environmental Parameters [PDF]
arXiv, 2010 Exchange of biochemical substances is essential way in establishing communication between bacterial cells. It is noticeable that all phases of the process are heavily influenced by perturbations of either internal or external parameters. Therefore, instead to develop an accurate quantitative model of substances exchange between bacterial cells, we are ...
arxiv
The separation of substances and estimation of their relative molecular sizes by the use of columns of starch in water [PDF]
, 1956 G. H. Lathe, C.R.J. Ruthven
openalex +1 more source
Cognitive impairment in substance use disorders
CNS Spectrums, 2018 Cognitive impairments in substance use disorders have been extensively researched, especially since the advent of cognitive and computational neuroscience and neuroimaging methods in the last 20 years.
Tatiana Ramey, P. Regier
semanticscholar +1 more source