Results 161 to 170 of about 54,698,481 (374)

An Assessment of Health Disparities among a Community Sample of LGBQ College Students [PDF]

open access: yes, 2018
Lesbian, gay, bisexual, and queer (LGBQ) individuals are a marginalized population in the United States, and this status places them at a greater risk for adverse health outcomes, such as tobacco and substance use, obesity, cancer, sexually-transmitted ...
Benotsch, Eric   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

WORKPLACE SUBSTANCE USE, THE RISK OF OCCUPATIONAL INJURY, AND TESTING [PDF]

open access: yes, 2005
Over the past 20 years, the "workplace substance abuse prevention industry" has grown enormously in size and has become more sophisticated in its marketing approach. Drug testing alone has become a $6 billion industry.
Zimbardi, Guy
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Juvenile substance use and effects of substance use disorder on incarceration and grade retention in a sample referred for court clinic mental health evaluation [PDF]

open access: yes, 2015
A significant amount of adolescents are involved in the drug court system. Within a few of the systems are mental health clinics providing more specific services to youth introduced into the courts.
Oliveira, Cassandra
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The classification of substance and behavioural addictions: A preliminary investigation [PDF]

open access: yes, 2012
The term addiction has been used to refer to impaired control over substance use for several centuries however recently there has been a shift toward using this term in the context of non-substance use disorders, such as pathological gambling.
McLaughlan, Andre David   +1 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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