Results 171 to 180 of about 2,260,368 (324)

Distinguishing Between Substance Use and Substance Use Disorder [PDF]

JAMA Internal Medicine, 2015
openaire   +2 more sources

Sociodemographic and psychiatric diagnostic predictors of 3-year incidence of DSM–IV substance use disorders among men and women in the National Epidemiologic Survey on Alcohol and Related Conditions.

, 2015
Risë B. Goldstein, Sharon Smith, Deborah A. Dawson, Bridget F. Grant   +3 more
openalex   +1 more source

An insight into the metabolism of New Psychoactive Substances : Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues using synthesized reference standards

, 2020
Jakob Wallgren
openalex   +2 more sources

Statement of the PPR Panel on a framework for conducting the environmental exposure and risk assessment for transition metals when used as active substances in plant protection products (PPP) [PDF]

, 2021
Antonio F. Hernández, Paulien Adriaanse, Annette Aldrich, Philippe Berny, Tamara Čoja, Sabine Duquesne, Andreas Focks, Marinovich Marina, Maurice Millet, Olavi Pelkonen, A. Tiktak, Christopher John Topping, Anneli Widenfalk, Martin F. Wilks, Gerrit Wolterink, Arnaud Conrad, Silvia Pieper, Silvia Pieper   +17 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Neural cognitive control moderates the longitudinal link between hedonia and substance use across adolescence

, 2022
Morgan Lindenmuth, Toria Herd, Alexis Brieant, Jacob Lee, Kirby Deater‐Deckard, Warren K. Bickel, Brooks King‐Casas, Jungmeen Kim‐Spoon   +7 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Bridging the gaps for women in substance use treatment. [PDF]

Front Psychiatry
Poole N.
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Prevalence of alcohol and substance use relapse in forensic inpatients with substance use disorders in Germany. [PDF]

Front Psychiatry
Düger S, Sörensen F, Völlm B.
europepmc   +1 more source