Results 191 to 200 of about 2,088,860 (358)

Polysubstance Use Is Not Synonymous With Poly Substance Use Disorder. [PDF]

Am J Public Health
Xu KY, Lin LA, Grucza RA.
europepmc   +1 more source

Substance P Radioimmunoassay Using N<SUP>α</SUP>-Tyrosyl-substance P and Demonstration of the Presence of Substance P-like Immunoreactivities in Human Blood and Porcine Tissue Extracts

, 1976
Chizuko Yanaihara, Haruko Sato, M Hirohashi, Masanori Sakagami, Kōichi Yamamoto, Tadashi Hashimoto, Noboru Yanaihara, Kaoru Abe, Toshio Kaneko   +8 more
openalex   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Lung Transplantation From Donors With a History of Substance Use. [PDF]

Clin Transplant
Li D, Weinkauf J, Hirji A, Weatherald J, Varughese R, van den Bosch L, Lien D, Nagendran J, Halloran K.   +8 more
europepmc   +1 more source

Uptake, Intracellular Transport and Degradation of Exogenous Protein by Langerhans Cells An Electron Microscopic-Cytochemical Study Using Peroxidase as Tracer Substance

, 1970
Klaus Wolff, Elisabeth Schreiner
openalex   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Use of psychoactive substances in three medical specialties: anaesthesia, medicine and surgery [PDF]

, 1994
I Lutsky, Margaret Hopwood, Stephen E. Abram, James M. Cerletty, Raymond G. Hoffman, John P. Kampine   +5 more
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Studies on active substances in herbs used for Oketsu ("stagnant blood") in Chinese medicine. VI On the anticoagulative principle in Paeoniae Radix.

, 1987
Hitoshi Ishida, MIKI TAKAMATSU, Kuniro Tsuji, Takuo Kosuge   +3 more
openalex   +2 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source