Results 211 to 220 of about 2,231,194 (294)

Developmentally tailored school-based interventions for substance use disorders: A narrative review. [PDF]

Indian J Psychiatry
Saha P, Muhammed JK, Chatterjee B, Dhawan A.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Substance Use of Older Adults in Gerontological Social Work Client Documents. [PDF]

Nordisk Alkohol Nark
Kaitala I, Zechner M, Karttunen T, Rossi E.   +3 more
europepmc   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Substance Use in Sports: A Cross-Sectional Study Among Professional Footballers in Accra, Ghana. [PDF]

Health Sci Rep
Odei I, Essuman YA, Ofori-Atta AL.
europepmc   +1 more source

Substance Use Disorder Privacy Workbook: 42 CFR Part 2 [PDF]

, 2017
Cameron, Stephanie, Doyle, Marcy, Hodder, Lucy C., Muniz, Christina, Ryer, Jeanne, EdD   +4 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Digital Therapies for Substance Use Disorders: Recent Advances and Engagement Strategies. [PDF]

Subst Abuse Rehabil
Oesterle TS, Bormann NL.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

A meta-analysis of sexual orientation inequities in substance use among youth. [PDF]

Addiction
Mereish EH, Lee H, Goldbach JT, Hathaway S, Hennessy EA.   +4 more
europepmc   +1 more source