Results 231 to 240 of about 15,452,334 (307)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comorbidities of substance use: Opportunities realized and future needs. [PDF]

J Subst Use Addict Treat
Feinberg J, Horigian V, Schmidt R, Feaster D, Metsch L, Hefner K, Shmueli-Blumberg D, Vena A, Hatch M, Ertl MM, Shoptaw S, Haynes L, Brown J, Korthuis PT, Masson C, Del Rio C, Tross S.   +16 more
europepmc   +1 more source

Substance use stigma mechanisms associated with greater depressive symptoms, substance use-related problems, and lower behavioral activation. [PDF]

Addict Behav Rep
Anvari MS, Sacko CA, Triplett NS, Bradley VD, Kleinman MB, Hines AC, Baskar R, Anane JS, Earnshaw VA, Belcher AM, Magidson JF.   +10 more
europepmc   +1 more source

Medicaid payment rates for substance use disorder treatment-design, data, and lack of transparency. [PDF]

Health Aff Sch
Tormohlen KN, Crable EL, McGinty EE.
europepmc   +1 more source

Suggestions for Culturally Adapted Interventions to Treat Substance Use in Immigrants. [PDF]

Cureus
Ram D, Margiotta KN, Julakanti P, Ownby RL.   +3 more
europepmc   +1 more source