Results 201 to 210 of about 53,729,253 (423)
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Western Maine Addiction and Recovery Initiative\u27s Substance Misuse Prevention and Wellness Day: Year 2 Feedback Survey for OHCHS [PDF]
As part of the evaluation of the Western Maine Addiction Recovery Initiative’s (WMARI) HRSA Rural Communities Opioid Response Program grant, staff from the Substance Use Research & Evaluation Unit, USM developed a survey to gather feedback from ...
Ali, Evelyn, BS +2 more
core +1 more source
Hepatitis C Virus Infection and Hospital-Related Outcomes: A Systematic Review
Canadian Journal of Gastroenterology and HepatologyBackground. People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use.
Michelle Ng +5 more
doaj +1 more source
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Use of unabsorbed radioactive marker substances in a re-assessment of the radioactive triolein test of fat absorption [PDF]
, 1971 RobertK. Ditchburn +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Using alone at home: What’s missing in housing-based responses to the overdose crisis?
Harm Reduction JournalBackground Against the backdrop of North America’s overdose crisis, most overdose deaths are occurring in housing environments, largely due to individuals using drugs alone.
Taylor Fleming +4 more
doaj +1 more source