Results 211 to 220 of about 54,698,481 (374)

Dissonance-Based Interventions for Substance Using Alternative High School Youth

, 2011
Lori Holleran Steiker, Tara Powell, Jeremy T. Goldbach, Laura M. Hopson   +3 more
openalex   +2 more sources

Reducing tobacco use in substance use treatment: An intervention to promote tobacco-free grounds

, 2021
Caravella McCuistian, Kwinoja Kapiteni, Thao Le, Jessica Safier, Kevin Delucchi, Joseph Guydish   +5 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Violence Risk Assessment in Individuals With Substance Use Disorders. [PDF]

Actas Esp Psiquiatr
Baljak VB, Zivlak-Radulovic N, Vicentic S.   +2 more
europepmc   +1 more source

Second and third year medical students’ self-reported alcohol and substance use, smoking habits and academic performance at a South African medical school [PDF]

, 2019
Annelize Vorster, Anthonie M. Gerber, Lynette J. Van der Merwe, Sanet van Zyl   +3 more
openalex   +1 more source

A potential role for the gut microbiome in substance use disorders

Psychopharmacology, 2019
Katherine R Meckel, D. Kiraly
semanticscholar   +1 more source

Personalizing the Treatment of Substance Use Disorders.

American Journal of Psychiatry, 2020
N. Volkow
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Substance Use, Poor Sleep, and Gestational Diabetes: Concerns in Adolescent Pregnancy. [PDF]

Sleep Sci
Dokkedal-Silva V, Hirata AE, Berro LF, Galduróz JCF, Tufik S, Andersen ML.   +5 more
europepmc   +1 more source